Negative relationship between fasting plasma ghrelin concentrations and ad libitum food intake
Negative relationship between fasting plasma ghrelin concentrations and ad libitum food intake
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DOI：
10.1210/jc.2003-032145
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发表时间：
2004-06-01
影响因子：
5.8
通讯作者：
Tataranni, PA
中科院分区：
文献类型：
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作者：
Salbe, AD;Tschöp, MH;Tataranni, PA
Ghrelin是一种具有促食欲作用的新型GH促分泌素。我们假设高空腹血浆ghrelin浓度（FxGhr）可能预示高自由采食量。在30名血糖正常的受试者中测量了FxGhr：15名皮马印第安人（8名男性/7名女性;年龄，32 ± 7岁;体重，87 ± 21 kg;平均值± SD）和15名高加索人（12名男性/3名女性，36 ± 8岁，94 ± 26 kg）在测试前3天的能量平衡。然后，受试者在接下来的3天内自由选择食物。平均每日能量摄入量（DEI）是根据所消耗食物的重量计算的，并表示为体重维持能量需求的百分比。高加索人的FxGhr是皮马印第安人的两倍（103 +/- 53 vs. 52 +/- 18 fmol/ml，P < 0.001），并且在调整年龄、性别和体重后仍然较高（P < 0.0001）。无论是DEI，还是维持体重所需能量的百分比，还是来自脂肪的卡路里的百分比，都没有种族之间的差异。在两组中，FxGhr与DEI呈负相关（分别为r =-0.61，P = 0.01; r=-0.54，P = 0.04）。这些负面关系无法用年龄、性别或体重的个体间差异来解释。低FxGhr预测随意食物摄入的这一意外发现表明内源性生长激素释放肽在能量稳态调节中的作用仍然不确定。
Ghrelin is a novel GH secretagogue with orexigenic effects. We hypothesized that high fasting plasma ghrelin concentrations (FxGhr) might predict high ad libitum food intake. FxGhr were measured in 30 normoglycemic subjects: 15 Pima Indians ( 8 male/7 female; age, 32 +/- 7 yr; body weight, 87 +/- 21 kg; mean +/- SD) and 15 Caucasians (12 male/3 female, 36 +/- 8 yr, 94 +/- 26 kg) in energy balance for 3 d before testing. Subjects then self-selected their food ad libitum for the following 3 d. Mean daily energy intake ( DEI) was calculated from the weight of foods consumed and expressed as a percent of weight maintenance energy needs. FxGhr were twice as high in Caucasians as in Pima Indians (103 +/- 53 vs. 52 +/- 18 fmol/ml, P < 0.001) and remained higher after adjustment for age, gender, and body weight ( P < 0.0001). Neither DEI, nor percent of weight maintenance energy needs, nor percent of calories from fat differed between the races. In both groups, FxGhr were negatively correlated with DEI (r = - 0.61, P = 0.01; r= - 0.54, P = 0.04, respectively). These negative relationships were not explained by interindividual differences in age, gender, or body weight. This unexpected finding that low FxGhr predict ad libitum food intake suggests that the role of endogenous ghrelin in the regulation of energy homeostasis remains uncertain.