Metastatic patterns at autopsy in patients with ovarian carcinoma
Metastatic patterns at autopsy in patients with ovarian carcinoma
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DOI：
10.1002/cncr.22919
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发表时间：
2007-09-15
期刊：
影响因子：
6.2
通讯作者：
Singer, Gad
中科院分区：
文献类型：
--
作者：
Gueth, Uwe;Huang, Dorothy Jane;Singer, Gad
背景以前发表的关于卵巢癌尸检结果的研究没有考虑到影响疾病进程的因素的广泛差异。此外，这些研究是在目前公认的诊断和治疗标准尚未完全确立的情况下进行的。本研究的目的是确定卵巢癌患者转移的频率和部位，特别关注临床病程和治疗。我们研究了1975年至2005年间死于卵巢癌的197例患者的尸检报告、组织学切片和临床资料。分析了转移部位（19个不同器官部位）和转移模式的分布，特别关注临床病程（年龄、生存期）和治疗（具有治愈目的的手术治疗、不同化疗方案）。总体而言，66.3%的患者转移到腹盆腔外的部位。年龄>70岁，疾病持续时间
BACKGROUND. Previously published studies concerning autopsy findings in ovarian cancer failed to consider the broad differences in factors that influence the course of disease. Furthermore, those studies were conducted when the currently accepted standards in diagnostics and therapy had not been fully established. The objective of the current study was to determine the frequency and sites of metastases in patients with ovarian cancer with particular attention to the clinical course and therapy.METHODS. Autopsy reports, histologic slides, and clinical files from 197 patients who died of ovarian carcinoma between 1975 and 2005 were studied. The distribution of metastatic sites (19 different organ sites) and metastatic patterns, with particular attention to clinical course (age, length of survival) and therapy (surgical treatment with curative intention, different chemotherapy regimens), were analyzed.RESULTS. Overall, 66.3% of patients had metastases to sites outside the abdominopelvic cavity. Patients who were aged >70 years, who had a disease duration