The janus face of lipids in human breast cancer: how polyunsaturated Fatty acids affect tumor cell hallmarks.
The janus face of lipids in human breast cancer: how polyunsaturated Fatty acids affect tumor cell hallmarks.
复制标题
DOI：
10.1155/2012/712536
复制
发表时间：
2012
影响因子：
1.9
通讯作者：
Blanckaert V
中科院分区：
文献类型：
--
作者：
Chénais B;Blanckaert V
多年来，脂质，尤其是n-3和n-6多不饱和脂肪酸（PUFA）在人类健康方面受到广泛关注。流行病学研究倾向于将富含 PUFA 的饮食与癌症（包括乳腺癌）发病率的降低联系起来。然而，支持 PUFA 对乳腺癌细胞作用的分子和细胞机制仍然相对未知。在此，我们回顾了 PUFA 对乳腺癌细胞增殖、凋亡、迁移和侵袭影响的最新进展。虽然用二十二碳六烯酸和/或二十碳五烯酸获得的大多数结果显示肿瘤细胞增殖和/或攻击性降低，但有一些证据表明在乳腺癌组织中积累的其他脂质（例如花生四烯酸）可能具有相反的作用。最后，脂质，尤其是多不饱和脂肪酸似乎可以作为传统癌症治疗的潜在佐剂。
For several years, lipids and especially n − 3 and n − 6 polyunsaturated fatty acids (PUFAs) receive much attention in human health. Epidemiological studies tend to correlate a PUFA-rich diet with a reduced incidence of cancer, including breast cancer. However, the molecular and cellular mechanisms supporting the effect of PUFAs in breast cancer cells remain relatively unknown. Here, we review some recent progress in understanding the impact that PUFA may have on breast cancer cell proliferation, apoptosis, migration, and invasion. While most of the results obtained with docosahexaenoic acid and/or eicosapentaenoic acid show a decrease of tumor cell proliferation and/or aggressivity, there is some evidence that other lipids, which accumulate in breast cancer tissues, such as arachidonic acid may have opposite effects. Finally, lipids and especially PUFAs appear as potential adjuvants to conventional cancer therapy.