Mean platelet volume as an inflammation marker in active pulmonary tuberculosis
Mean platelet volume as an inflammation marker in active pulmonary tuberculosis
复制标题
DOI：
10.1186/2049-6958-9-11
复制
发表时间：
2014-01-01
影响因子：
2.3
通讯作者：
Altin, Sedat
中科院分区：
文献类型：
--
作者：
Gunluoglu, Gulsah;Yazar, Esra Ertan;Altin, Sedat
背景：平均血小板体积（MPV）反映血小板的大小。在某些慢性炎症性疾病中，它与炎症水平呈负相关。这项前瞻性研究旨在通过与健康对照组的比较，显示MPV作为活动性肺结核（PTB）患者炎症标志物的可用性。此外，它与其他炎症标志物，如C-反应蛋白（CRP）和红细胞沉降率（ESR），以及与疾病的放射学程度的关系examined.Methods：本研究包括82例活动性PTB和95名健康人（对照组）。比较两组患者的全血细胞计数、C反应蛋白（CRP）水平及血沉（ESR）。在PTB组中，研究了疾病的放射学范围与MPV和其他炎症标记物之间的关系。结果：PTB组的MPV为7.74 +/- 1.33/μ L，对照组为8.20 +/- 1.13/μ L（p = 0.005）。活动性肺结核组血小板计数、CRP、ESR均显著高于对照组（P < 0.0001）。在PTB组中，CRP（r = 0.26，p = 0.003）和ESR（r = 0.39，p = 0.003）与PTB患者的MPV（p = 0.80）无显著相关性，但与PTB患者的MPV显著相关。MPV不能反映疾病的严重程度。在PTB中使用MPV作为炎症标志物和阴性急性期反应物似乎并不可靠。
Background: The mean platelet volume (MPV) reflects the size of platelets. It has been shown to be inversely correlated with level of the inflammation in some chronic inflammatory diseases. This prospective study aims to show the usability of MPV as an inflammation marker in patients with active pulmonary tuberculosis (PTB) by comparison with healthy controls. In addition, its relationships with other inflammatory markers such as C-reactive protein (CRP) and the erythrocyte sedimentation rate (ESR) as well as with the radiological extent of disease were examined.Methods: This study included 82 patients with active PTB and 95 healthy subjects (control group). Whole blood counts, CRP level, and ESR were compared between the two groups. In the PTB group, the relationships between the radiological extent of disease and the MPV and other inflammation markers were investigated.Results: The MPV was 7.74 +/- 1.33/mu L in the PTB group and 8.20 +/- 1.13/mu L in the control group (p = 0.005). The blood platelet count, CRP level, and ESR were significantly higher in the active PTB group than in the control group (p < 0.0001). In the PTB group, CRP levels (r = 0.26, p = 0.003) and ESR (r = 0.39, p = 0.003), but not MPV (p = 0.80), were significantly correlated with the radiologic extent of the disease.Conclusions: The MPV was lower in patients with PTB than in healthy controls, however, the difference was limited. The MPV does not reflect the severity of the disease. The use of MPV as an inflammation marker and a negative acute-phase reactant in PTB does not seem to be reliable.