ACTIVATION PARAMETERS AND STEREOCHEMISTRY OF AN ANTIBODY-CATALYZED CLAISEN REARRANGEMENT
ACTIVATION PARAMETERS AND STEREOCHEMISTRY OF AN ANTIBODY-CATALYZED CLAISEN REARRANGEMENT
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DOI：
10.1002/anie.199201821
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发表时间：
1992-02-01
期刊：
影响因子：
--
通讯作者：
SCHULTZ, PG
中科院分区：
文献类型：
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作者：
JACKSON, DY;LIANG, MN;SCHULTZ, PG
通过不同的机制催化相同的反应归因于免疫应答的多样性。 分支酸盐-预苯酸盐转化1 -> 3可以被针对过渡态2的类似物产生的抗体催化。 这些抗体产生用于催化的多种活化参数。 发现抗体11 F1 - 2 E11的活化熵极低，这支持构象限制可能在抗体催化中起重要作用的观点。
The catalysis of the same reaction through different mechanisms was attributed to the diversity of the immune response. The chorismate-prephenate conversion 1 --> 3 can be catalyzed by antibodies raised against an analogue of the transition state 2. These antibodies give rise to a variety of activation parameters for the catalysis. An extremely low activation entropy was found for the antibody 11F1-2E11, which supports the notion that conformational restriction may play an important role in antibody catalysis.