Lesion of the ventral and intermediate hippocampus abolishes anticipatory activity in the medial prefrontal cortex of the rat
Lesion of the ventral and intermediate hippocampus abolishes anticipatory activity in the medial prefrontal cortex of the rat
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DOI：
10.1016/j.bbr.2008.11.045
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发表时间：
2009-05-16
影响因子：
2.7
通讯作者：
Poucet, Bruno
中科院分区：
文献类型：
--
作者：
Burton, Brian G.;Hok, Vincent;Poucet, Bruno
大鼠的内侧前额叶皮质（mPFC）接收来自海马腹侧三分之二的显著输入，海马是一个对空间意识、工作记忆和动机非常重要的结构。我们最近发现[Hok V, Lenck - Santini PR, Roux S, Save E, Muller RU, Poucet B. 海马位置细胞中与目标相关的活动。《神经科学杂志》2007年；27:472 - 82]，在操作性任务中食物丸释放之前，背侧海马的神经元表现出预期性放电。在此，我们在同一任务中寻找mPFC中的类似活动，并测试这种活动是否依赖于海马。大鼠被训练导航至一个目标区域，等待食物丸的释放，然后寻找食物丸，同时在mPFC的前边缘区和下边缘区记录单位活动。每天进行两个16分钟的实验阶段，一个阶段目标由一个提示圆盘界定，另一个阶段没有提示。在对照组中，当动物在目标处静止时，很大比例的mPFC神经元表现出与在海马中看到的类似的活动。超过一半的神经元无论目标位置如何都表现出相同的活动。在双侧腹侧和中间海马损伤的动物中，无论是有提示还是无提示的阶段，预期性活动在很大程度上都消失了，尽管损伤的动物仍然能够执行任务，但它们往往会过早地离开目标区域。我们认为，mPFC中的预期性活动依赖于海马中的类似活动，并且这两个结构在冲动控制或奖赏预期中都起作用。(C) 2008爱思唯尔B.V. 保留所有权利。
The medial prefrontal cortex (mPFC) of the rat receives a prominent input from the ventral two thirds of the hippocampus, a Structure important for spatial awareness, working memory and motivation. We recently found [Hok V, Lenck-Santini PR Roux S, Save E, Muller RU, Poucet B. Goal-related activity in hippocampal place cells. J Neurosci 2007;27:472-82.] that neurones in the dorsal hippocampus exhibit anticipatory firing Prior to the release ON food pellet on an operant task. Here we look for similar activity in the mPFC on the same task and test whether this activity is dependent on the hippocampus. Rats were trained to navigate to a goal zone. wait for the release of a food pellet and then forage for the pellet while unit activity was recorded in the prelimbic and infralimbic areas of the mPEC. Two 16 min sessions were conducted per day, one session with the goal delimited by a cue disc, the second without the Cue. In controls, a large proportion of mPEC neurones exhibited activity similar to that seen in the hippocampus while the animal was stationary at the goal. Over half exhibited the same activity regardless of goal location. Anticipatory activity was largely abolished in animals with bilateral lesions of the ventral and intermediate hippocampus, both in cued and uncued sessions, Even though lesioned animals continued to perform the task, they tended to leave the goal zone prematurely. We suggest that the anticipatory activity in the mPFC is dependent on similar activity in the hippocampus and that both Structures have a role in either impulse control or reward expectation. (C) 2008 Elsevier B.V. All rights reserved.