Motor-Related Signals in the Intraparietal Cortex Encode Locations in a Hybrid, rather than Eye-Centered Reference Frame
Motor-Related Signals in the Intraparietal Cortex Encode Locations in a Hybrid, rather than Eye-Centered Reference Frame
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DOI：
10.1093/cercor/bhn207
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发表时间：
2009-08-01
期刊：
影响因子：
3.7
通讯作者：
Groh, Jennifer M.
中科院分区：
文献类型：
--
作者：
Mullette-Gillman, O'Dhaniel A.;Cohen, Yale E.;Groh, Jennifer M.
顶叶内皮层神经元用来编码位置的参考框架是有争议的。许多先前的研究已经提出了以眼为中心的编码，而我们已经报道了视觉和听觉信号采用混合参考系（即，以头部和眼睛为中心的信息的组合）（Mullette-Gillman等人，2005年）。对这种差异的一个可能的解释是，我们之前研究过的感觉相关活动是混合的，而运动相关活动可能是以眼睛为中心的。在这里，我们研究了参考框架的视觉和听觉扫视相关的活动在外侧和内侧银行的顶内沟（地区外侧顶内区[LIP]和内侧顶内区[MIP]）的2只恒河猴。我们记录了275个单神经元的猴子从不同的初始眼睛位置进行视觉和听觉扫视。我们发现，视觉和听觉信号都反映了一个混合的头和眼为中心的坐标在目标和perisaccadic任务期间，而不是转移到眼睛为中心的格式作为扫视接近。这一说法与以往的许多记录研究不同。我们认为，在以前的研究中的感受野采样的几何形状是偏向于以眼为中心的参考系。因此，参考框架的整体混合性质被忽视，因为非眼睛为中心的反应模式没有得到充分的表征。
The reference frame used by intraparietal cortex neurons to encode locations is controversial. Many previous studies have suggested eye-centered coding, whereas we have reported that visual and auditory signals employ a hybrid reference frame (i.e., a combination of head- and eye-centered information) (Mullette-Gillman et al. 2005). One possible explanation for this discrepancy is that sensory-related activity, which we studied previously, is hybrid, whereas motor-related activity might be eye centered. Here, we examined the reference frame of visual and auditory saccade-related activity in the lateral and medial banks of the intraparietal sulcus (areas lateral intraparietal area [LIP] and medial intraparietal area [MIP]) of 2 rhesus monkeys. We recorded from 275 single neurons as monkeys performed visual and auditory saccades from different initial eye positions. We found that both visual and auditory signals reflected a hybrid of head- and eye-centered coordinates during both target and perisaccadic task periods rather than shifting to an eye-centered format as the saccade approached. This account differs from numerous previous recording studies. We suggest that the geometry of the receptive field sampling in prior studies was biased in favor of an eye-centered reference frame. Consequently, the overall hybrid nature of the reference frame was overlooked because the non-eye-centered response patterns were not fully characterized.