Validity of Peripheral Arterial Disease Diagnoses in the Danish National Patient Registry
Validity of Peripheral Arterial Disease Diagnoses in the Danish National Patient Registry
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DOI：
10.1016/j.ejvs.2016.12.031
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发表时间：
2017-05-01
影响因子：
5.7
通讯作者：
Gronholdt, M. -L. M.
中科院分区：
文献类型：
--
作者：
Lasota, A. N.;Overvad, K.;Gronholdt, M. -L. M.
目的/背景：目的是验证从丹麦国家登记处获得的腿部外周动脉疾病 (PAD) 的诊断。方法：丹麦国家患者登记处总共从丹麦饮食、癌症和健康队列研究的 57,053 名中年参与者中发现了 1435 例登记的 PAD 病例。通过使用预先指定的 PAD 诊断标准审查所有医疗记录来进行验证。结果：PAD 诊断的总体阳性预测值 (PPV) 为 69.4% [95% 置信区间 (CI) 67.0-71.7]。血管外科的诊断 PPV 显着高于其他科室的诊断：分别为 71.9% (95% CI 69.2-74.4) 和 58.3% (95% CI 52.2-64.2)。在一项子研究中，对也在丹麦国家血管登记处登记的 141 例潜在 PAD 病例进行了评估，发现这些诊断的 PPV 为 87.9%（95% CI 81.4-92.4）。 结论：丹麦国家患者登记处通报的 PAD 诊断中，超过 30% 无效，这强调了在将登记信息用于研究目的时进行验证的重要性。相比之下，从丹麦国家血管登记处获得的诊断具有很高的有效性，无需进一步验证即可使用。 (C) 2017 年欧洲血管外科学会。由爱思唯尔有限公司出版。保留所有权利。
Objectives/Background: The objective was to validate the diagnoses of peripheral arterial disease (PAD) in the legs, obtained from national registers in Denmark.Methods: In total, 1435 registered cases of PAD were identified in the Danish National Patient Registry among 57,053 middle aged participants from the Danish Diet, Cancer and Health cohort study. Validation was performed by reviewing all medical records using pre-specified criteria for a diagnosis of PAD.Results: The overall positive predictive value (PPV) of PAD diagnoses was 69.4% [95% confidence interval (CI) 67.0-71.7]. The PPV of diagnoses given in departments of vascular surgery was significantly higher than diagnoses given in other departments: 71.9% (95% CI 69.2-74.4) versus 58.3% (95% CI 52.2-64.2), respectively. In a sub-study, 141 potential cases of PAD also registered in the Danish National Vascular Registry were evaluated, and a PPV of 87.9% (95% CI 81.4-92.4) was found for these diagnoses.Conclusion: More than 30% of the diagnoses of PAD notified in the Danish National Patient Registry were not valid, stressing the importance of validation when using register information for research purposes. In contrast, diagnoses obtained from the Danish National Vascular Registry had a high validity ready for use without further validation. (C) 2017 European Society for Vascular Surgery. Published by Elsevier Ltd. All rights reserved.