Copper(I) alkoxide-catalyzed alkynylation of trifluoromethyl ketones
Copper(I) alkoxide-catalyzed alkynylation of trifluoromethyl ketones
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DOI：
10.1021/ol071003k
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发表时间：
2007-08-02
期刊：
影响因子：
5.2
通讯作者：
Shibasaki, Masakatsu
中科院分区：
文献类型：
--
作者：
Motoki, Rie;Kanai, Motomu;Shibasaki, Masakatsu
提出了一种以(CuOBu)-Bu-t-xantphos或邻菲咯啉为催化剂的三氟甲基酮直接烷基化反应的通用方法。配体的加入显著提高了催化剂的活性。此外，催化剂制备过程中生成的KOTf具有一定的加速作用。还描述了催化对映体选择性CF3取代的叔丙醇合成(高达52%ee)的初步扩展。
A general method for direct alkynylation of trifluoromethyl ketones was developed by using (CuOBu)-Bu-t-xantphos or phenanthroline complexes as catalysts. The ligands significantly enhanced the catalyst activity. In addition, KOTf, generated in the catalyst preparation step, exhibited some acceleration effects. A preliminary extension to a catalytic enantioselective CF3-substituted tertiary propargyl alcohol synthesis (up to 52% ee) is also described.