Novel Parameters to Assess the Severity of Corneal Neovascularization Using Anterior Segment Optical Coherence Tomography Angiography
Novel Parameters to Assess the Severity of Corneal Neovascularization Using Anterior Segment Optical Coherence Tomography Angiography
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DOI：
10.1016/j.ajo.2020.08.023
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发表时间：
2021-02-01
影响因子：
4.2
通讯作者：
Hamrah, Pedram
中科院分区：
文献类型：
--
作者：
Binotti, William W.;Koseoglu, N. Dilruba;Hamrah, Pedram
目得：评估前段光学相干断层扫描血管造影（AS-OCTA），以确定角膜新生血管（CoNV）的严重程度。设计：回顾性，横断面，单中心研究。方法：选择各种CoNV病因的患者，并将其分为轻度，中度和重度。测量其AS-OCTA图像的CoNV前界、CoNV后界、CoNV厚度、CoNV深度%、CoNV血管密度、CoNV面积和CoNV体积。此外，AS-OCTA参数与临床参数相关，如分类，数字严重程度量表，血管时钟小时数和最佳矫正视力（BCVA）。结果：共有19只轻度，10只中度和6只重度CoNV眼睛，年龄性别差异无统计学意义。CoNV深度%和体积从轻度增加至中度（分别为9.3 ± 1.1%至17.7 ± 3.3%，P = 0.030和0.2 ± 0.1 mm（3）至1.0 ± 0.3 mm（3），P = 0.025）和中度至重度CoNV（分别为44.6 ± 5.3%，P < .001和2.0 ± 0.3 mm（3），P = .014）。CoNV面积和后界从轻度增加到中度（分别为1.7 +/- 0.3 mm（2）至4.6 +/- 0.7 mm（2），P = 0.001和217.7 +/- 16.8 μ m至349.1 +/- 54.9 μ m，P = 0.048），未从中度至重度（P = 0.999和P = 0.403）。CoNV厚度从中度增加到重度（218.2 +/- 46.6 μ m到340.2 +/- 8.7 μ m，P = 0.020），但不是从轻度增加到中度。CoNV面积和体积与CoNV分期（分别为r = 0.703和r = 0.771; P <0.001）和严重程度（分别为r = 0.794和r = 0.712; P <0.001）具有良好的相关性。CoNV面积与时钟时间呈良好的相关性（r = 0.749，P <0.001）。CoNV深度和体积与BCVA具有良好的相关性（分别为r = 0.744和r = 0.722; P <0.001）。CoNV前界和血管密度显示无显著相关性（P >=.05）。结论：与轻度相比，重度CoNV在AS-OCTA上显示出更大的CoNV后界、厚度、深度%、面积和体积。CoNV体积和深度与BCVA强烈相关。AS-OCTA为评估CoNV严重程度提供了新的、定量的和无创的参数。(C)2020爱思唯尔公司All rights reserved.
PURPOSE: Assessment of anterior segment-optical coherence tomography angiography (AS-OCTA) to determine severity of corneal neovascularization (CoNV).DESIGN: Retrospective, cross-sectional, single-center study.METHODS: Patients of various CoNV etiologies were selected and classified into mild, moderate, and severe. Their AS-OCTA images were measured for CoNV anterior limit, CoNV posterior limit, CoNV thickness, CoNV depth%, CoNV vessel density, CoNV area, and CoNV volume. Further, AS-OCTA parameters were correlated to clinical parameters, such as classification, a numerical severity scale, vascular clock hours, and best-corrected visual acuity (BCVA).RESULTS: A total of 19 mild, 10 moderate, and 6 severe CoNV eyes were included with no significant age-gender differences. CoNV depth% and volume increased from mild to moderate (9.3 +/- 1.1% to 17.7 +/- 3.3%, P = .030, and 0.2 +/- 0.1 mm(3) to 1.0 +/- 0.3 mm(3), P = .025, respectively) and from moderate to severe CoNV (44.6 +/- 5.3%, P < .001, and 2.0 +/- 0.3 mm(3), P = .014, respectively). CoNV area and posterior limit increased from mild to moderate (1.7 +/- 0.3 mm(2) to 4.6 +/- 0.7 mm(2) , P = .001, and 217.7 +/- 16.8 mu m to 349.1 +/- 54.9 mu m, P = .048, respectively), not from moderate to severe (P = .999 and P = .403, respectively). CoNV thickness increased from moderate to severe (218.2 +/- 46.6 mu m to 340.2 +/- 8.7 mu m, P = .020), but not from mild to moderate. CoNV area and volume showed good correlations to CoNV staging (r = 0.703 and r = 0.771, respectively; P < .001) and severity scale (r = 0.794 and r = 0.712, respectively; P < .001). CoNV area showed good corre- lation to clock hours (r = 0.749, P < .001). CoNV depth and volume showed good correlation to BCVA (r = 0.744 and r = 0.722, respectively; P < .001). CoNV anterior limit and vessel density showed no significant correlations (P >=.05).CONCLUSIONS: Severe CoNV shows greater CoNV posterior limit, thickness, depth%, area, and volume on AS-OCTA compared to mild. CoNV volume and depth strongly correlate to BCVA. AS-OCTA provides novel, quantitative, and noninvasive parameters for assessing CoNV severity. (C) 2020 Elsevier Inc. All rights reserved.