Phantom and in vivo study of the Look-Locher T1 mapping method
Phantom and in vivo study of the Look-Locher T1 mapping method
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DOI：
10.1016/s0730-725x(99)00078-8
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发表时间：
1999-12-01
影响因子：
2.5
通讯作者：
Nordell, B
中科院分区：
文献类型：
--
作者：
Karlsson, M;Nordell, B
本文介绍和测试的LL EPI方法获得定量T-1估计在几秒钟内，从而允许动态T-1的研究。它示出，该方法的作品，即使当有一个流入到成像体积，例如，在一个血管。无需校准。该方法已在体模研究中进行了测试，具有几种不同的扫描参数设置，有和没有流入。该方法显示了鲁棒性，单个扫描参数和流入速率不影响计算Gd-DTPA浓度的能力，在150 < T-1 < 2500 ms的范围内，测量的1/T-1和Gd-DTPA浓度之间存在线性关系。显示动态LL-EPI T-1映射技术比来自T-2* 加权EPI序列的信号灵敏三倍。在体内研究中，动态T-1映射的Gd-DTPA摄取脑膜瘤进行。摄取曲线的检查表明该方法在临床灌注研究中是可行的，（C）1999 Elsevier Science Inc.
This paper describes and tests the LL EPI method for obtaining quantitative T-1 estimates in a few seconds thereby allowing dynamic T-1 studies. It is shown that the method works even when there is an inflow into the imaged volume, e,g,, in a vessel. No calibration is needed. The method has been tested in a phantom study with several different scan parameter set-ups, with and without inflow. The method shows robustness and individual scan parameters and inflow rates do not influence the ability to calculate the Gd-DTPA concentration, Linearity prevail between the measured 1/T-1 and the Gd-DTPA concentration in the range 150 < T-1 < 2500 ms. In a dynamic Gd-DTPA phantom study, it was shown that the dynamic LL-EPI T-1 mapping technique was three times more sensitive than the signal from a T-2*-weighted EPI sequence. In an in vivo study, dynamic T-1 mapping of the Gd-DTPA uptake in a meningioma was performed. Inspection of the uptake curves indicates that the method is feasible in clinical perfusion studies, (C) 1999 Elsevier Science Inc.