Animal behavioral assessments in current research of Parkinson's disease
Animal behavioral assessments in current research of Parkinson's disease
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当前帕金森病研究中的动物行为评估
DOI：
10.1016/j.neubiorev.2016.03.016
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发表时间：
2016-06-01
影响因子：
8.2
通讯作者：
Xia, Ying
中科院分区：
文献类型：
--
作者：
Asakawa, Tetsuya;Fang, Huan;Xia, Ying
帕金森病（PD）是一种神经退行性疾病，传统上被归类为运动障碍。患者通常患有多种运动功能障碍。目前，临床医生和科学家认识到许多非运动症状与PD有关。PD患者的运动和非运动症状的临床研究以及模拟PD患者病理生理特征和症状的动物模型的实验室研究越来越受到关注。因此，适当的行为评估对于正确认识帕金森病的发病机制，准确评估新疗法的疗效和安全性至关重要。本文系统地综述了目前PD研究中涉及的各种动物模型的运动和非运动症状的行为评估。我们讨论了这些行为测试的优点和缺点以及它们的适当应用。此外，我们还讨论了这些行为测试背后的潜在机制，并提醒读者注意潜在的实验偏见。由于目前大多数用于非运动症状的行为评估都不是专门针对PD动物设计的，因此在PD动物模型研究中，大幅改进实验设计和评估是至关重要的。事实上，根据PD动物的特征对其非运动症状进行具体评估是必要的。最后，我们展望了在未来PD研究中使用移动互联网和可穿戴设备进行实时评估的行为评估。(C) 2016 Elsevier Ltd.版权所有。
Parkinson's disease (PD), a neurodegenerative disorder, is traditionally classified as a movement disorder. Patients typically suffer from many motor dysfunctions. Presently, clinicians and scientists recognize that many non-motor symptoms are associated with PD. There is an increasing interest in both motor and non-motor symptoms in clinical studies on PD patients and laboratory research on animal models that imitate the pathophysiologic features and symptoms of PD patients. Therefore, appropriate behavioral assessments are extremely crucial for correctly understanding the mechanisms of PD and accurately evaluating the efficacy and safety of novel therapies. This article systematically reviews the behavioral assessments, for both motor and non-motor symptoms, in various animal models involved in current PD research. We addressed the strengths and weaknesses of these behavioral tests and their appropriate applications. Moreover, we discussed potential mechanisms behind these behavioral tests and cautioned readers against potential experimental bias. Since most of the behavioral assessments currently used for non-motor symptoms are not particularly designed for animals with PD, it is of the utmost importance to greatly improve experimental design and evaluation in PD research with animal models. Indeed, it is essential to develop specific assessments for non-motor symptoms in PD animals based on their characteristics. We concluded with a prospective view for behavioral assessments with real-time assessment with mobile internet and wearable device in future PD research. (C) 2016 Elsevier Ltd. All rights reserved.