Bmi1+ Progenitor Cell Dynamics in Murine Cornea During Homeostasis and Wound Healing.
Bmi1+ Progenitor Cell Dynamics in Murine Cornea During Homeostasis and Wound Healing.
复制标题
DOI：
10.1002/stem.2767
复制
发表时间：
2018-04
期刊：
影响因子：
--
通讯作者：
Michon F
中科院分区：
文献类型：
--
作者：
Kalha S;Shrestha B;Sanz Navarro M;Jones KB;Klein OD;Michon F
The outermost layer of the eye, the cornea, is renewed continuously throughout life. Stem cells of the corneal epithelium reside in the limbus at the corneal periphery and ensure homeostasis of the central epithelium. However, in young mice, homeostasis relies on cells located in the basal layer of the central corneal epithelium. Here, we first studied corneal growth during the transition from newborn to adult and assessed Keratin 19 (Krt19) expression as a hallmark of corneal maturation. Next, we set out to identify a novel marker of murine corneal epithelial progenitor cells before, during and after maturation, and we found that Bmi1 is expressed in the basal epithelium of the central cornea and limbus. Furthermore, we demonstrated that Bmi1+ cells participated in tissue replenishment in the central cornea. These Bmi1+ cells did not maintain homeostasis of the cornea for more than three months, reflecting their status as progenitor rather than stem cells. Finally, after injury, Bmi1+ cells fueled homeostatic maintenance, whereas wound closure occurred via epithelial reorganization.
登录
查看更多内容
在哺乳动物组织形态发生中，细胞嵌入产生的力牵引表皮片。
影响因子：
11.8
作者：
Heller, Evan;Kumar, K. Vijay;Grill, Stephan W.;Fuchs, Elaine
通讯作者：
Fuchs, Elaine
影响因子：
1.2
作者：
Douvaras, Panagiotis;Webb, Sheila;West, John D.
通讯作者：
West, John D.
影响因子：
--
作者：
Mort RL;Ramaesh T;Kleinjan DA;Morley SD;West JD
通讯作者：
West JD
DOI：
10.1083/jcb.200703003
发表时间：
2007-06-18
期刊：
The Journal of cell biology
影响因子：
--
作者：
Barbaro V;Testa A;Di Iorio E;Mavilio F;Pellegrini G;De Luca M
通讯作者：
De Luca M
影响因子：
1.2
作者：
Dorà NJ;Hill RE;Collinson JM;West JD
通讯作者：
West JD