Recent insights into the effect of natural and environmental estrogens on mammary development and carcinogenesis
Recent insights into the effect of natural and environmental estrogens on mammary development and carcinogenesis
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DOI：
10.1387/ijdb.113369vp
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发表时间：
2011-01-01
影响因子：
0.7
通讯作者：
Leclercq, Guy
中科院分区：
文献类型：
--
作者：
Pelekanou, Vassiliki;Leclercq, Guy
目前的工作回顾了最近的研究结果有关的行动甾体（生理）雌激素对正常乳腺发育和癌变，以及相关的环境介质（植物和异种雌激素）的影响，其中的作用仍然存在争议。雌激素受体（即ER α和ER β）和上皮细胞生长、凋亡和分化的辅助调节因子的表达指导了我们的分析。同时还研究了上皮和基质之间的双向协调与干性的维持。ER和其他最终的雌激素结合位点的核和核外定位的相关性，介导关于这些不同的主题的差分动作，是严格处理，以描绘直接和间接激活程序和微妙的反馈回路（配体诱导或/和串扰激活，分别）的重要性。在预防和治疗乳腺癌的药物设计计划中纳入概述的监管概念可能会产生有效的影响。
The present work reviews recent findings related to the action of steroidal (physiological) estrogens on normal mammary gland development and carcinogenesis, as well as effects of related environmental mediators (phyto- and xeno-estrogens), the role of which remains controversial. Orchestration by estrogen receptors (i.e. ER alpha and ER beta) and coregulators of growth, apoptosis and differentiation of epithelial cells, directed our analysis. The bidirectional coordination between epithelium and stroma in parallel with maintenance of stemness are also investigated. The relevance of nuclear and extranuclear localization of ERs and other eventual estrogen binding sites, mediating differential actions in regard to these various topics, is critically addressed to delineate the importance of direct and indirect activation procedures and delicate feedback loops (ligand-induced or/and cross-talk activation, respectively). The inclusion of the outlined regulatory concepts in drug design programs for the prevention and treatment of breast cancer may have potent effects.