Role of positron emission tomography/computed tomography findings for adjuvant chemotherapy indications in stage T1b-2aN0M0 lung adenocarcinoma
Role of positron emission tomography/computed tomography findings for adjuvant chemotherapy indications in stage T1b-2aN0M0 lung adenocarcinoma
复制标题
正电子发射断层扫描/计算机断层扫描结果对 T1b-2aN0M0 期肺腺癌辅助化疗指征的作用
DOI：
10.1016/j.athoracsur.2014.04.080
复制
发表时间：
2014
影响因子：
4.6
通讯作者：
Okada M
中科院分区：
文献类型：
--
作者：
Sasada S;Miyata Y;Tsubokawa N;Mimae T;Yoshiya T;Okada M
背景本研究旨在确定18F-氟脱氧葡萄糖正电子发射断层扫描/计算机断层扫描的最大标准化摄取值（SUVmax）的意义方法我们根据术前FDG-PET/CT检查的SUVmax值评估无复发间隔期（RFI）和总生存期（OS）。连续174例完全切除病理分期T1 b-2aN 0 M0肺腺癌患者的CT图像。结果90例患者接受了辅助化疗，84例患者未接受辅助化疗。与观察组相比，辅助化疗对RFI和OS有益处（分别为p= 0.007和p = 0.004）。多因素考克斯回归分析显示SUV max是RFI的独立预后因素。在SUVmax ≥ 2.6的患者中，接受辅助化疗的患者的RFI和OS显著长于未接受辅助化疗的患者（分别为p< 0.001和p < 0.001）。然而，在SUVmax小于2.6的患者组中，RFI和OS没有显著差异（分别为p= 0.421和p = 0.452.ConclusionsPreoperative SUVmax determined from FDG-PET/CT images reflect the effect of adjuvant chemotherapy after complete removal in patients with pathological stage T1 b-2aN 0 M0 lung adenocarcinoma.根据FDG-PET/CT图像的SUVmax和肿瘤大小，可以更准确地确定肺腺癌患者术后辅助化疗的指征。
BackgroundThis study aimed to determine the significance of the maximum standardized uptake value (SUVmax) on 18F-fluorodeoxyglucose positron emission tomography/computed tomography (FDG-PET/CT) images on postoperative adjuvant chemotherapy for lung adenocarcinoma.MethodsWe assessed recurrence-free interval (RFI) and overall survival (OS) based on SUVmaxvalues derived from preoperative FDG-PET/CT images in 174 consecutive patients with completely resected pathologic stage T1b-2aN0M0 lung adenocarcinoma.ResultsNinety patients received adjuvant chemotherapy and 84 did not. Adjuvant chemotherapy conferred benefits on RFI and OS when compared with observation (p= 0.007 andp= 0.004, respectively). Multivariate Cox regression analyses revealed SUVmaxas an independent prognostic factor for RFI. RFI and OS were significantly longer for patients who received adjuvant chemotherapy compared with those who did not in the group with SUVmaxgreater than or equal to 2.6 (p< 0.001 andp< 0.001, respectively). However, RFI and OS did not differ significantly between such patients in the group with SUVmaxless than 2.6 (p= 0.421 andp= 0.452, respectively).ConclusionsPreoperative SUVmaxdetermined from FDG-PET/CT images reflected the effect of adjuvant chemotherapy after complete resection in patients with pathologic stage T1b-2aN0M0 lung adenocarcinoma. Indications for postoperative adjuvant chemotherapy among patients with lung adenocarcinoma might be more precisely determined using SUVmaxderived from FDG-PET/CT images together with tumor size.