Metabolic heterogeneity in cancer: An overview and therapeutic implications
Metabolic heterogeneity in cancer: An overview and therapeutic implications
复制标题
癌症的代谢异质性：概述和治疗意义
DOI：
10.1016/j.bbcan.2020.188421
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发表时间：
2020
影响因子：
11.2
通讯作者：
Yanfeng Liu
中科院分区：
文献类型：
--
作者：
Yu Tong;Wei-Qiang Gao;Yanfeng Liu
最近对癌症代谢的研究表明，个体肿瘤具有高度异质性的代谢特征，这有助于肿瘤及其环境内的结缔代谢网络。事实上，肿瘤相关细胞类型，包括肿瘤细胞、癌症相关成纤维细胞（CAF）和免疫细胞，由于不同的遗传背景和复杂的环境刺激，以多种不同的方式重新编程其代谢。这种肿瘤内代谢异质性和衍生的代谢相互作用在癌症进展中发挥着重要作用。了解这种异质性是如何发生的可能会提供有希望的治疗策略。在这里，我们回顾了肿瘤中几个重要细胞亚群的不同代谢特征及其对肿瘤进展的影响，并讨论了随后的代谢相互作用以及相关的治疗问题。
Recent research on cancer metabolism has revealed that individual tumors have highly heterogeneous metabolic profiles that contribute to the connective metabolic networks within the tumor and its environment. Indeed, tumor-associated cells types, including tumor cells, cancer-associated fibroblasts (CAFs) and immune cells, reprogram their metabolism in many different ways due to diverse genetic backgrounds and complex environmental stimuli. This intratumoral metabolic heterogeneity and the derived metabolic interactions play an instrumental role in cancer progression. Understanding how this heterogeneity occurs may provide promising therapeutic strategies. Here, we review the diverse metabolic profiles of several important cell subpopulations in tumors and their impact on tumor progression and discuss the consequent metabolic interactions as well as the related therapeutic concerns.