Visuospatial Organization and Recall in Cerebellar Ataxia
Visuospatial Organization and Recall in Cerebellar Ataxia
复制标题
DOI：
10.1007/s12311-018-0948-z
复制
发表时间：
2019-02-01
期刊：
影响因子：
3.5
通讯作者：
Marvel, Cherie
中科院分区：
文献类型：
--
作者：
Slapik, Mitchell;Kronemer, Sharif I.;Marvel, Cherie
视觉空间技能不佳会扰乱日常生活活动。小脑与视觉空间处理有关，小脑损伤的患者通常表现出较差的视觉空间技能，这是通过 Rey-Osterrieth 复杂图形任务 (ROCF) 中的图形记忆受损来衡量的。视觉空间技能是 ROCF 的一个固有方面；然而，图形组织（即参与者重建图形的顺序）会影响回忆能力。本研究的目的是检查和比较小脑性共济失调患者的视觉空间和组织技能。我们对诊断为小脑共济失调的患者和健康对照进行 ROCF。小脑共济失调组包括诊断为脊髓小脑共济失调（任何亚型）、常染色体显性小脑共济失调或病因不明的小脑共济失调的患者。主要结果指标是 ROCF 的组织和回忆表现，以及来自视觉空间感知、工作记忆、处理速度和运动功能的认知测试的补充信息。与对照组相比，小脑性共济失调患者的身材组织受损。患者的图形复制受到损害，但他们随后的回忆表现正常，这表明最初的组织和复制策略得到了补偿。在对照组中，图形组织可以预测回忆能力，但在患者中没有观察到这种关系。相反，处理速度可以预测患者的回忆准确性。补充任务表明，小脑共济失调组的视觉感知完好无损，并且表现缺陷与组织策略的关系比与视觉空间技能的关系更密切。
Poor visuospatial skills can disrupt activities of daily living. The cerebellum has been implicated in visuospatial processing, and patients with cerebellar injury often exhibit poor visuospatial skills, as measured by impaired memory for the figure within the Rey-Osterrieth complex figure task (ROCF). Visuospatial skills are an inherent aspect of the ROCF; however, figure organization (i.e., the order in which the figure is reconstructed by the participant) can influence recall ability. The objective of this study was to examine and compare visuospatial and organization skills in people with cerebellar ataxia. We administered the ROCF to patients diagnosed with cerebellar ataxia and healthy controls. The cerebellar ataxia group included patients that carried a diagnosis of spinocerebellar ataxia (any subtype), autosomal dominant cerebellar ataxia, or cerebellar ataxia with unknown etiology. Primary outcome measures were organization and recall performance on the ROCF, with supplemental information derived from cognitive tests of visuospatial perception, working memory, processing speed, and motor function. Cerebellar ataxia patients revealed impaired figure organization relative to that of controls. Figure copy was impaired in the patients, but their subsequent recall performance was normal, suggesting compensation from initial organization and copying strategies. In controls, figure organization predicted recall performance, but this relationship was not observed in the patients. Instead, processing speed predicted patients' recall accuracy. Supplemental tasks indicated that visual perception was intact in the cerebellar ataxia group and that performance deficits were more closely tied to organization strategies than with visuospatial skills.