Possible role of the JAK/STAT pathways in the regulation of T cell-interferon related genes in systemic lupus erythematosus
Possible role of the JAK/STAT pathways in the regulation of T cell-interferon related genes in systemic lupus erythematosus
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DOI：
10.1177/0961203311409963
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发表时间：
2011-10-01
期刊：
影响因子：
2.6
通讯作者：
Sekigawa, I.
中科院分区：
文献类型：
--
作者：
Kawasaki, M.;Fujishiro, M.;Sekigawa, I.
检测系统性红斑狼疮（SLE）患者中与疾病进展相关的CD 3 + T细胞基因表达的变化。确定了与SLE疾病相关活动相关的基因，并对其基因调控网络进行了研究。基因表达的分析通过DNA微阵列和实时定量逆转录聚合酶链反应（qRT-PCR）进行。某些基因的表达，包括干扰素（IFN）调节因子（IRF）相关基因，如IFN调节，相关，和签名基因的SLE活动期增加。通路网络分析表明，这些IRF相关基因的调控通过Janus激酶/信号转导和转录激活因子（JAK/STAT）途径。JAK/STAT通路介导的IRF相关基因的调节可能在SLE的疾病活动中起重要作用。JAK/STAT级联的抑制剂可用作治疗剂。Lupus（2011）20，1231-1239.
Changes in gene expression in CD3+ T cells associated with disease progression in systemic lupus erythematosus (SLE) patients were determined. The genes related to SLE disease-related activities were identified and their gene regulatory networks were investigated. Analyses of gene expression were performed by both DNA microarray and real-time quantitative reverse transcription polymerase chain reaction (qRT-PCR). The expression of certain genes including interferon (IFN) regulatory factor (IRF)-related genes, such as IFN-regulated, -related, and -signature genes was increased in the active phase of SLE. Pathway network analyses suggested that these IRF-related genes are regulated through the Janus kinase/signal transducer and activator of transcription (JAK/STAT) pathway. JAK/STAT pathway-mediated regulation of IRF-related genes may have an important role in the disease activity of SLE. Inhibitors of JAK/STAT cascade may be useful as therapeutic agents. Lupus (2011) 20, 1231-1239.