No Association Between the Protein Tyrosine Phosphatase, Receptor-Type, Z Polypeptide 1 (PTPRZ1) Gene and Schizophrenia in the Japanese Population
No Association Between the Protein Tyrosine Phosphatase, Receptor-Type, Z Polypeptide 1 (PTPRZ1) Gene and Schizophrenia in the Japanese Population
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DOI：
10.1002/ajmg.b.30692
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发表时间：
2008-10-05
影响因子：
2.8
通讯作者：
Ozaki, Norio
中科院分区：
文献类型：
--
作者：
Ito, Yoshihito;Yamada, Shinnosuke;Ozaki, Norio
NRG 1-ERBB信号传导影响精神分裂症病理学风险最近的一项研究报道，MAGI 1，MAGI 2和蛋白酪氨酸磷酸酶，受体型，Z多肽1（PTPRZ 1;位于7q31.3）基因产物调节NRG 1-ERBB 4信号通路，PTPRZ 1与高加索人群中的精神分裂症相关。通过应用基于基因的关联概念，我们分析了日本人群（576名精神分裂症患者和768名对照）中PTPRZ 1标记SNP与精神分裂症之间的任何关联。连锁不平衡后。分析中，使用5 '-外切核酸酶等位基因辨别测定对29个单核苷酸多态性（SNP）进行基因分型。我们在基因型分析中发现了一个标签SNP的显著相关性（P = 0.007）;然而，这可能是由于多重检验导致的I型错误（SNPSpD校正后P = 0.17）。在等位基因、基因型或单倍型分析中，均未观察到精神分裂症患者与对照组之间存在关联。因此，我们的研究结果表明，PTPRZ 1不太可能与日本人群中精神分裂症的发展有关。(C)2008威利利斯公司
NRG1-ERBB signaling influences the risk for schizophrenia pathology. A recent study has reported that MAGI1, MAGI2, and protein tyrosine phosphatase, receptor-type, Z polypeptide 1 (PTPRZ1; located on 7q31.3) gene products regulate the NRG1-ERBB4 signaling pathway, and PTPRZ1 is associated with schizophrenia in a Caucasian population. By applying a gene-based association concept, we analyzed any association between PTPRZ1 tagging SNPs and schizophrenia in the Japanese population (576 schizophrenics and 768 controls). After linkage disequilibrium. analysis, 29 single nucleotide polymorphisms (SNPs) were genotyped using a 5'-exonuclease allelic discrimination assay. We found a significant association of one tagging SNP in a genotype-wise analysis (P = 0.007); however, this might be resulted from type I error due to multiple testing (P = 0.17 after SNPSpD correction). No association was observed between schizophrenic patients and controls in either allelic, genotypic, or haplotypic analyses. Our results therefore suggest that PTPRZ1 is unlikely to be related to the development of schizophrenia in the Japanese population. (C) 2008 Wiley-Liss, Inc.