Somatic EPSP amplitude is independent of synapse location in hippocampal pyramidal neurons
Somatic EPSP amplitude is independent of synapse location in hippocampal pyramidal neurons
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DOI：
10.1038/78800
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发表时间：
2000-09-01
影响因子：
25
通讯作者：
Cook, EP
中科院分区：
文献类型：
--
作者：
Magee, JC;Cook, EP
大多数神经元接受成千上万的突触输入到广泛分布的树突上。由于树突的过滤作用，远端突触的效能应该比近端突触低。为了研究这一点，我们的特点是兴奋性突触输入的幅度和动力学的CA1锥体神经元的顶树突使用双全细胞记录。我们发现，树突的EPSP振幅增加与距离索马，抵消了树突的过滤效果，降低了躯体EPSP振幅的位置依赖性。树枝状电流注入和多隔室计算机模型表明，树枝状膜特性在提高局部EPSP方面只起很小的作用。相反，突触传导的逐渐增加似乎是使单个输入的振幅正常化的主要原因。
Most neurons receive thousands of synaptic inputs onto widely spread dendrites. Because of dendritic filtering, distant synapses should have less efficacy than proximal ones. To investigate this, we characterized the amplitude and kinetics of excitatory synaptic input across the apical dendrites of CA1 pyramidal neurons using dual whole-cell recordings. We found that dendritic EPSP amplitude increases with distance from the soma, counterbalancing the filtering effects of the dendrites and reducing the location dependence of somatic EPSP amplitude. Dendritic current injections and a multi-compartmental computer model demonstrated that dendritic membrane properties have only a minor role in elevating the local EPSP. Instead a progressive increase in synaptic conductance seems to be primarily responsible for normalizing the amplitudes of individual inputs.