Striatal and Extrastriatal Dopamine Transporter Availability in Schizophrenia and Its Clinical Correlates: A Voxel-Based and High-Resolution PET Study
Striatal and Extrastriatal Dopamine Transporter Availability in Schizophrenia and Its Clinical Correlates: A Voxel-Based and High-Resolution PET Study
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DOI：
10.1093/schbul/sbw192
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发表时间：
2017-09-01
影响因子：
6.6
通讯作者：
Trichard, Christian
中科院分区：
文献类型：
--
作者：
Artiges, Eric;Leroy, Claire;Trichard, Christian
多巴胺（DA）功能的神经影像学研究广泛支持精神分裂症患者突触前纹状体DA功能亢进的假说。然而，发表的数据纹状体DA转运蛋白（DAT）似乎不太符合这一假设，可能部分是由于方法的局限性。此外，在精神分裂症的背景下，纹状体外区域的DAT研究非常少。为了解决这些问题，我们使用了高分辨率正电子发射断层扫描仪和选择性DAT放射性配体[C-11] PE 2 I，再加上全脑体素为基础的分析方法，以调查DAT的可用性在纹状体，但也纹状体外区域在21例男性慢性精神分裂症患者与30名健康男性对照组的年龄相匹配。我们发现精神分裂症患者在中脑、纹状体和边缘区的DAT可用性更高。杏仁核/海马和壳核/苍白球的DAT可用性分别与幻觉和怀疑/迫害呈正相关。这些结果与精神分裂症患者突触前DA功能增加一致，并支持纹状体和纹状体外DA功能障碍参与阳性精神病症状。该研究还强调了基于全脑体素的分析方法，以探讨精神分裂症的DA功能障碍。
Neuroimaging studies investigating dopamine (DA) function widely support the hypothesis of presynaptic striatal DA hyperactivity in schizophrenia. However, published data on the striatal DA transporter (DAT) appear less consistent with this hypothesis, probably partly due to methodological limitations. Moreover, DAT in extrastriatal regions has been very poorly investigated in the context of schizophrenia. In order to address these issues, we used a high resolution positron emission tomograph and the selective DAT radioligand [C-11]PE2I, coupled with a whole brain voxel-based analysis method to investigate DAT availability in striatal but also extra-striatal regions in 21 male chronic schizophrenia patients compared to 30 healthy male controls matched by age. We found higher DAT availability in schizophrenia patients in midbrain, striatal, and limbic regions. DAT availability in amygdala/hippocampus and putamen/pallidum was positively correlated with hallucinations and suspiciousness/persecution, respectively. These results are consistent with an increase of presynaptic DA function in patients with schizophrenia, and support the involvement of both striatal and extrastriatal DA dysfunction in positive psychotic symptoms. The study also highlights the whole brain voxel-based analysis method to explore DA dysfunction in schizophrenia.