A novel systemic inflammation response index (SIRI) for predicting postoperative survival of patients with esophageal squamous cell carcinoma
A novel systemic inflammation response index (SIRI) for predicting postoperative survival of patients with esophageal squamous cell carcinoma
复制标题
一种用于预测食管鳞状细胞癌患者术后生存的新型全身炎症反应指数（SIRI）
DOI：
10.1016/j.intimp.2018.10.002
复制
发表时间：
2018-12-01
影响因子：
5.6
通讯作者：
Wu, Changping
中科院分区：
文献类型：
--
作者：
Geng, Yiting;Zhu, Danxia;Wu, Changping
背景：炎症与肿瘤的发生、发展密切相关。根据外周血中性粒细胞、单核细胞和淋巴细胞计数，建立一种新的全身炎症反应指数（SIRI），用于预测食管鳞癌（ESCC）患者术后生存率。生存分析表明，SIRI 1.2的患者中位总生存期（OS）。与TNM分期系统相比，SIRI列线图能更准确地预测OS。此外，SIRI从基线到术后8周的变化与患者生存相关。SIRI升高> 75%的患者的OS较无变化的患者差，SIRI降低> 75%或在25%与75%相近的范围内的患者的OS较好。结论：SIRI是食管鳞癌根治术后独立的预后指标。整合SIRI的诺模图可帮助临床医生筛选高危患者，制定个体化治疗方案。
Background: Inflammation is closely associated with the initiation and development of tumors. Based on the counts of peripheral neutrophils, monocytes and lymphocytes, we established a new systemic inflammation response index (SIRI) to predict postoperative survival of patients with esophageal squamous cell carcinoma (ESCC).Methods: A total of 916 ESCC patients treated with radical esophagectomy were enrolled in the present study.Results: Survival analysis indicated that the median overall survival (OS) in patients with SIRI 1.2. The nomogram including SIRI could more accurately predict OS compared with the TNM staging system. In addition, the changes of SIRI from baseline to 8 weeks after the operation were correlated with patient survival. The patients with an increase in SIRI > 75% had worse OS compared with those with no change, while the patients with a decrease in SIRI > 75% or in the scope of 25% similar to 75% exhibited better OS.Conclusions: SIRI was an independent prognostic index of ESCC patients after the radical resection. The nomogram integrating the SIRI could help clinicians to screen the high-risk patients and formulate the individualized treatment schemes.