Associations between polymorphisms in the AHR and CYP1A1-CYP1A2 gene regions and habitual caffeine consumption
Associations between polymorphisms in the AHR and CYP1A1-CYP1A2 gene regions and habitual caffeine consumption
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DOI：
10.3945/ajcn.112.038794
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发表时间：
2012-09-01
影响因子：
7.1
通讯作者：
El-Sohemy, Ahmed
中科院分区：
文献类型：
--
作者：
Josse, Andrea R.;Da Costa, Laura A.;El-Sohemy, Ahmed
背景：最近来自欧洲血统人群的全基因组关联研究(GWASs)发现，芳香烃受体(AHR)和细胞色素P450 1A1和1A2基因的单核苷酸多态(SNPs)和细胞色素P450 1A1和1A2(CYP1A1-Cy1PA2)基因与习惯性摄入咖啡因和咖啡有关。目的：我们研究了这些SNP(AHR：rs6968865和rs4410790；CYP1A1-CYP1A2：rs2472297和rs2470893)和另外6个标签SNPs是否与哥斯达黎加人群习惯性摄入咖啡因有关。设计：受试者来自一项关于基因-饮食相互作用和心肌梗死的病例对照研究。有高血压或缺少吸烟、咖啡因摄入量或基因信息的受试者被排除在外。结果：与每日摄入400 mg咖啡因的受试者相比，携带T、C和T等位基因的受试者分别为rs6968865、rs4410790和rs2472297。OR值和95%CI分别为1.41(1.03，1.93)、1.41(1.04，1.92)和1.55(1.01，2.36)。所有受试者的多变量调整OR(95%CI)为1.44(1.03，2.00)，非吸烟者为1.75(1.16，2.65)，现吸烟者为1.15(0.58，2.30)，57岁以上受试者为2.42(1.45，4.04)，受试者为1.00(0.65，1.56
Background: Recent genome-wide association studies (GWASs) from populations of European descent identified single nucleotide polymorphisms (SNPs) in aryl-hydrocarbon receptor (AHR) and cytochrome P450 1A1 and 1A2 (CYP1A1-CY1PA2) genes that are associated with habitual caffeine and coffee consumption.Objective: We examined whether these SNPs (AHR: rs6968865 and rs4410790; CYP1A1-CYP1A2: rs2472297 and rs2470893) and 6 additional tag SNPs in the AHR gene were associated with habitual caffeine consumption in a Costa Rican population.Design: Subjects were from a case-control study of gene-diet interactions and myocardial infarction. Subjects with hypertension or missing information on smoking, caffeine intake, or genotype were excluded. Subjects were genotyped by using polymerase chain reaction with mass spectrometry based detection, and caffeine intake was assessed by using a validated food-frequency questionnaire.Results: Compared with subjects who consumed 400 mg caffeine/d were more likely to be carriers of the T, C, or T allele for rs6968865, rs4410790, and rs2472297, respectively. The corresponding ORs and 95% CIs were 1.41 (1.03, 1.93), 1.41 (1.04, 1.92), and 1.55 (1.01, 2.36). Multivariate-adjusted ORs (95% CIs) for rs6968865 were 1.44 (1.03, 2.00) for all subjects, 1.75 (1.16, 2.65) for nonsmokers, 1.15 (0.58, 2.30) for current smokers, 2.42 (1.45, 4.04) for subjects >57 y old, and 1.00 (0.65, 1.56) for subjects