Natural killer cells in breast cancer cell growth and metastasis in SCID mice
Natural killer cells in breast cancer cell growth and metastasis in SCID mice
复制标题
DOI：
10.1016/s0753-3322(05)80082-4
复制
发表时间：
2005-10-01
影响因子：
7.5
通讯作者：
Yamamoto, N
中科院分区：
文献类型：
--
作者：
Dewan, MZ;Terunuma, H;Yamamoto, N
自然杀伤(NK)细胞是天然免疫系统的重要组成部分，在宿主抵抗肿瘤和病毒感染的细胞中起着核心作用。本文就小鼠NK细胞在严重联合免疫缺陷(SCID)小鼠乳腺癌细胞生长和转移中的作用作一综述。传统的SCID和NOD-SCID株已被用于研究人类肿瘤的异种移植。SCID小鼠的癌症模型模拟人类疾病，并提供了有价值的信息。然而，这些小鼠品系具有一些残留的免疫力，如NK细胞，这在一定程度上限制了人类异种移植瘤的生长和转移。相比之下，NOD/SCID/Gamma c(Null)(NOG)小鼠没有共同的伽马链接种乳腺癌细胞，在形成大肿瘤和转移方面最有效。无NK活性的NOG小鼠品系似乎更有希望成为人类肿瘤异种移植的工具。这种新的异种移植模型是相关的，可以推荐用于阐明癌细胞的生长机制以及开发新的抗癌治疗策略。(C)2005年爱思唯尔集团。版权所有。
Natural killer (NK) cell is an important component of the innate immune system and plays a central role in host defense against tumor and virus-infected cells. This review briefly summarizes the role of murine NK cells in tumor growth and metastasis of breast cancer cells in severe combined immunodeficiency (SCID) mice. Conventional SCID and NOD-SCID strains have been used to study for xenotransplantion of human tumors. SCID mice models of cancer mimic human diseases and have provided valuable information. However, these mice strains have some residual immunity such as NK cells that somewhat limit post-transplantation growth and metastasis of human xenografts. In contrast, NOD/SCID/gamma c(null) (NOG) mice without common gamma-chain inoculated with breast cancer cells were most efficient in the formation of a large tumor and metastasis. NOG mouse strain without NK activity appears to be more promising as tool for xenotransplantion of human cancer. This new xenotransplant model is relevant and can be recommended for use in clarifying the mechanism of growth of cancer cells as well as for developing new therapeutic strategies against cancer. (c) 2005 Elsevier SAS. All rights reserved.