Novel Therapeutic Targets in Cutaneous Squamous Cell Carcinoma.
Novel Therapeutic Targets in Cutaneous Squamous Cell Carcinoma.
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DOI：
10.3389/fonc.2018.00079
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发表时间：
2018
影响因子：
4.7
通讯作者：
Hata H
中科院分区：
文献类型：
--
作者：
Yanagi T;Kitamura S;Hata H
皮肤鳞状细胞癌（SCC）是白种人常见的恶性肿瘤之一，约占皮肤恶性肿瘤的20-30%。大多数患者转移的风险较低;然而，侵袭性SCC与非常高的死亡率和发病率相关。虽然皮肤鳞状细胞癌可以通过手术切除、放疗和化疗单独或联合治疗，但转移性鳞状细胞癌患者的预后很差。最近，免疫检查点封锁的使用正在考虑之中。为了开发比现有疗法毒性更小的有效疗法，关键是要详细描述皮肤SCC发病机制的分子机制，并确定新的药物靶点。最近的研究已经确定了与SCC癌变和进展相关的新分子。这篇综述集中在涉及SCC肿瘤发展的分子研究的最新进展，以及临床医生可用的新疗法。
Cutaneous squamous cell carcinoma (SCC) is one of the common cancers in Caucasians, accounting for 20–30% of cutaneous malignancies. The risk of metastasis is low in most patients; however, aggressive SCC is associated with very high mortality and morbidity. Although cutaneous SCC can be treated with surgical removal, radiation and chemotherapy singly or in combination, the prognosis of patients with metastatic SCC is poor. Recently, the usage of immune checkpoint blockades has come under consideration. To develop effective therapies that are less toxic than existing ones, it is crucial to achieve a detailed characterization of the molecular mechanisms that are involved in cutaneous SCC pathogenesis and to identify new drug targets. Recent studies have identified novel molecules that are associated with SCC carcinogenesis and progression. This review focuses on recent advances in molecular studies involving SCC tumor development, as well as in new therapeutics that have become available to clinicians.
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影响因子：
4.7
作者：
Argiris A;Harrington KJ;Tahara M;Schulten J;Chomette P;Ferreira Castro A;Licitra L
通讯作者：
Licitra L
影响因子：
13.8
作者：
Fujisawa, Yasuhiro;Umebayashi, Yoshihiro;Otsuka, Fujio
通讯作者：
Otsuka, Fujio
影响因子：
11.5
作者：
Biktasova, Asel;Hajek, Michael;Issaeva, Natalia
通讯作者：
Issaeva, Natalia
影响因子：
3.3
作者：
Nakamura, Kenta;Okuyama, Ryuhei;Uhara, Hisashi
通讯作者：
Uhara, Hisashi
DOI：
10.1158/1078-0432.ccr-11-1951
发表时间：
2012-03-01
期刊：
Clinical cancer research : an official journal of the American Association for Cancer Research
影响因子：
--
作者：
Lewis CM;Glisson BS;Feng L;Wan F;Tang X;Wistuba II;El-Naggar AK;Rosenthal DI;Chambers MS;Lustig RA;Weber RS
通讯作者：
Weber RS