An optimized lanthanide-chlorophyll nanocomposite for dual-modal imaging-guided surgery navigation and anti-cancer theranostics
An optimized lanthanide-chlorophyll nanocomposite for dual-modal imaging-guided surgery navigation and anti-cancer theranostics
复制标题
用于双模态成像引导手术导航和抗癌治疗诊断的优化镧系元素-叶绿素纳米复合材料
DOI：
10.1039/c9bm02057h
复制
发表时间：
2020
期刊：
影响因子：
--
通讯作者：
Lv Ruichan
中科院分区：
文献类型：
--
作者：
Wang Yanxing;Lu Wei-Dong;Lin Bi;Yang Fan;Feng Miao;Lv Ruichan
在这项研究中，设计了一种优化的荧光粉与天然绿色叶绿素(Ph-chl)相结合，用于双模式发光引导的抗肿瘤手术和光动力学治疗(PDT)。采用遗传算法(GA)对荧光粉中各元素的比例进行编码，解决了上转换发光(UCL)和短波红外(SWIR)强度低的问题，从而找到了芯层Yb/Er和壳层Yb/Nd的最佳上转换发光强度和SWIR发光增强的荧光粉。此外，当不同发光颜色的荧光粉(蓝色和绿色)与叶绿素组合时，结果表明，以红色发光为能量供体的荧光粉具有较高的光转化效率，可以激活叶绿素产生活性氧物种(ROS)。此外，由于增强的穿透和滞留(EPR)效应，合成的Ph-chl可以用于手术导航，具有更高的SWIR成像效果，聚焦于癌症而不是正常组织和癌旁组织。因此，最终优化后的荧光粉的高双模发光引导手术性能将促进其在微创内窥镜临床手术导航中的进一步应用。
In this research, an optimized phosphor combined with naturally green chlorophyll (Phosphor-Chlorophyll, denoted as Ph-chl) was designed for dual-modal luminescence-guided anti-tumor surgery and photodynamic therapy (PDT). A genetic algorithm (GA) is used to solve the “low up-conversion luminescence (UCL) and short-wavelength infrared (SWIR) intensity” problem by coding the proportions of elements in the phosphor in order to find the optimal phosphor with enhanced red UCL emission and SWIR luminescence using Yb/Er in the core and Yb/Nd in the shell. Moreover, when phosphors with different emission light colors (blue and green) are combined with chlorophyll as the control, the results indicate that phosphors with red emission as the energy donor have high PDT efficiency to activate the chlorophyll for reactive oxygen species (ROS) production. Additionally, due to the enhanced penetration and retention (EPR) effect, the as-synthesized Ph-chl could be used for surgery navigation with a higher SWIR imaging effect focusing on cancer rather than normal tissues and paracancerous tissue. Thus, the high dual-modal luminescence guided surgery properties of the final optimized phosphor will promote its further use in minimally-invasive endoscopic clinical surgery navigation.