A fully organic retinal prosthesis restores vision in a rat model of degenerative blindness.
A fully organic retinal prosthesis restores vision in a rat model of degenerative blindness.
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DOI：
10.1038/nmat4874
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发表时间：
2017-06
期刊：
影响因子：
41.2
通讯作者：
Benfenati F
中科院分区：
文献类型：
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作者：
Maya-Vetencourt JF;Ghezzi D;Antognazza MR;Colombo E;Mete M;Feyen P;Desii A;Buschiazzo A;Di Paolo M;Di Marco S;Ticconi F;Emionite L;Shmal D;Marini C;Donelli I;Freddi G;Maccarone R;Bisti S;Sambuceti G;Pertile G;Lanzani G;Benfenati F
视网膜中光感受器的变性是人类成年失明的主要原因之一。不幸的是，对于大多数视网膜退行性疾病没有有效的临床治疗。在这里，我们报告的制造和功能验证的一个完全有机的假体长期在体内视网膜下植入的皇家外科学院大鼠的眼睛，广泛认可的模型视网膜色素变性。电生理和行为分析显示，光敏感度和视敏度的恢复依赖于假体，并持续到术后6-10个月。正电子发射断层扫描成像显示，视觉功能的恢复伴随着初级视皮层基础代谢活动的增加。我们的研究结果强调了开发新一代完全有机，高度生物相容性和功能自主的光伏假体用于视网膜下植入治疗退行性失明的可能性。
The degeneration of photoreceptors in the retina is one of the major causes of adult blindness in humans. Unfortunately, no effective clinical treatments exist for the majority of retinal degenerative disorders. Here we report on the fabrication and functional validation of a fully organic prosthesis for long-term in vivo subretinal implantation in the eye of Royal College of Surgeons rats, a widely recognized model of Retinitis pigmentosa. Electrophysiological and behavioral analyses reveal a prosthesis-dependent recovery of light-sensitivity and visual acuity that persists up to 6-10 months after surgery. The rescue of the visual function is accompanied by an increase in the basal metabolic activity of the primary visual cortex, as demonstrated by positron emission tomography imaging. Our results highlight the possibility of developing a new generation of fully organic, highly biocompatible and functionally autonomous photovoltaic prostheses for subretinal implants to treat degenerative blindness.