New diagnostic techniques in staging in the surgical treatment of cutaneous malignant melanoma.
New diagnostic techniques in staging in the surgical treatment of cutaneous malignant melanoma.
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DOI：
10.1053/ejso.2002.1319
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发表时间：
2002-11
期刊：
影响因子：
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通讯作者：
Dc Cobben;S. Koopal;A. Tiebosch;P. Jager;P. Elsinga;T. Wobbes;H. Hoekstra
中科院分区：
文献类型：
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作者：
Dc Cobben;S. Koopal;A. Tiebosch;P. Jager;P. Elsinga;T. Wobbes;H. Hoekstra
对黑色素瘤外科治疗的研究重点集中在手术切缘、高危患者选择性淋巴清扫的作用以及马法兰热隔离淋巴灌流辅助区域治疗的价值。在这项研究的同时，还开发了新的诊断技术，如正电子发射断层扫描和采用免疫组织化学标记物和逆转录聚合酶链式反应等先进实验室方法进行前哨淋巴结活检，以促进转移性黑色素瘤的早期检测。本文讨论了这些新技术在黑色素瘤分期和外科治疗中的作用。
The emphasis of the research on the surgical treatment of melanoma has been on the resection margins, the role of elective lymph node dissection in high risk patients and the value of adjuvant regional treatment with hyperthermic isolated lymph perfusion with melphalan. Parallel to this research, new diagnostic techniques, such as Positron Emission Tomography and the introduction of the sentinel lymph node biopsy with advanced laboratory methods such as immuno-histochemical markers, and reverse transcriptase polymerase chain reaction, have been developed to facilitate early detection of metastatic melanoma. The role of these new techniques on the staging and surgical treatment of melanoma is discussed in this paper.