Transforming growth factor-beta signaling in breast cancer
Transforming growth factor-beta signaling in breast cancer
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DOI：
10.2741/2396
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发表时间：
2007-05-01
影响因子：
3.1
通讯作者：
Cao, Deliang
中科院分区：
文献类型：
--
作者：
Chang, Ching-Fang;Westbrook, Reyhan;Cao, Deliang
Transforming growth factor-beta (TGF-beta) is a multifunctional polypeptide that regulates cell growth, differentiation, and extracellular matrix formation. Studies on genetically engineered animal models have demonstrated that TGF-beta-mediated signaling pathway plays a critical role in both normal development and tumorigenesis of the breast. In pathogenesis of breast cancer, the role of TGF-beta appears featured with growth-inhibitory effects at early stages of carcinogenesis, but aggressive oncogenesis with transition to more advanced malignant states. The TGF-beta signaling pathway is also tissue-context and ligand content-dependent. Therein, therapeutic modulation of TGF-beta signaling may be a multifactorial event.
