Cytokines as endogenous pyrogens
Cytokines as endogenous pyrogens
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DOI：
10.1086/513856
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发表时间：
1999-03-01
影响因子：
6.4
通讯作者：
Dinarello, CA
中科院分区：
文献类型：
--
作者：
Dinarello, CA
细胞因子是介导多种病理过程的多效性分子。早在细胞因子作为免疫系统生长因子或骨髓刺激剂被发现之前，研究人员在将细胞因子作为发烧的内源性介质进行研究时，就已经对它们有了很多了解。术语“粒细胞”或“内源性热原”被用来描述具有致热生物学特性的物质。今天，我们认识到致热性是几种细胞因子的基本生物学特性，因此临床上可识别的发热特性将疾病期间宿主的扰动与细胞生物学的基本扰动联系在一起。在这篇综述中，对内源性热原的发现进行了重新回顾，并深入了解了早期工作对当今理解细胞因子在健康和疾病中的重要性。
Cytokines are pleiotropic molecules mediating several pathologic processes. Long before the discovery of cytokines as immune system growth factors or as bone marrow stimulants, investigators learned a great deal about cytokines when they studied them as the endogenous mediators of fever. The terms "granulocytic" or "endogenous pyrogen" were used to describe substances with the biologic property of fever induction. Today, we recognize that pyrogenicity is a fundamental biologic property of several cytokines and hence the clinically recognizable property of fever links host perturbations during disease with fundamental perturbations in cell biology. In this review, the discoveries made on endogenous pyrogens are revisited, with insights into the importance of the earlier work to the present-day understanding of cytokines in health and in disease.