Caregiving Disruptions Affect Growth and Pubertal Development in Early Adolescence in Institutionalized and Fostered Romanian Children: A Randomized Clinical Trial.
Caregiving Disruptions Affect Growth and Pubertal Development in Early Adolescence in Institutionalized and Fostered Romanian Children: A Randomized Clinical Trial.
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DOI：
10.1016/j.jpeds.2018.07.027
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发表时间：
2018-12
期刊：
影响因子：
--
通讯作者：
Drury SS
中科院分区：
文献类型：
--
作者：
Johnson DE;Tang A;Almas AN;Degnan KA;McLaughlin KA;Nelson CA;Fox NA;Zeanah CH;Drury SS
确定寄养与机构照顾的影响，以及在青少年早期的身体发育的发育环境中断。这是一项随机对照试验，纳入了114名来自罗马尼亚布加勒斯特6个孤儿院的住院儿童（尽管其他方面都很健康）和51名从未住院的对照儿童（家庭护理组）。儿童从基线（21个月，范围5-31）到12岁的发育中断和生长轨迹和14岁的青春期发育。随机分配到寄养组的儿童在12岁时的身高、体重和体重指数（BMI）增长率高于机构化组。坦纳的发展被推迟在制度化组男孩相比，寄养组和家庭照顾组男孩在12岁，但不是14岁。寄养组、机构组和家庭照顾组女孩在12岁和14岁时的坦纳发育和初潮年龄没有差异。在30个月和12年之间的中断更多的缓和身高增长率的下降在寄养组和寄养组和机构化组的年龄。在12岁时，受到≥2次干扰的机构组男孩的坦纳评分低于受到<2次干扰的机构组和寄养组男孩。寄养组中有≥2次中断的女孩在14岁时的坦纳评分高于寄养组中有<2次中断的女孩。月经初潮年龄不受月经中断的影响。对于那些经历过早期机构化的儿童来说，稳定的家庭照料对于确保身体发育的最佳结果至关重要。clinicaltrials.gov：NCT 00747396。
To determine the effects of foster care vs institutional care, as well as disruptions in the caregiving environment on physical development through early adolescence. This was a randomized controlled trial of 114 institutionalized, though otherwise healthy, children from 6 orphanages and 51 never institutionalized control children living in birth families (family care group) in Bucharest, Romania. Children were followed from baseline (21 months, range 5–31) through age 12 years for caregiving disruptions and growth trajectories and through age 14 years for pubertal development. Children randomized to the foster care group showed greater rates of growth in height, weight, and body mass index (BMI) through age 12 years than institutionalized group. Tanner development was delayed in institutionalized group boys compared with foster care group and family care group boys at 12 but not 14 years. There were no differences in Tanner development and age of menarche among foster care group, institutionalized group, and family care group girls at ages 12 and 14 years. More disruptions in caregiving between 30 months and 12 years moderated decreases in growth rates of height in foster care group and weight in foster care group and institutionalized group across age. institutionalized group boys with ≥2 disruptions showed lower Tanner scores at age 12 vs institutionalized group and foster care group boys with <2 disruptions. foster care group girls with ≥2 disruptions had higher Tanner scores at age 14 vs foster care group girls with <2 disruptions. Age of menarche was not affected by caregiving disruptions. For children who experienced early institutionalization, stable placement within family care is essential to ensuring the best outcomes for physical developmental. clinicaltrials.gov: NCT00747396.
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DOI：
10.1111/j.1540-5834.2011.00629.x
发表时间：
2011-01-01
影响因子：
9.5
作者：
Johnson, Dana E.;Gunnar, Megan R.
通讯作者：
Gunnar, Megan R.
影响因子：
3.1
作者：
Kerker, Bonnie D.;Zhang, Jinjin;Horwitz, Sarah McCue
通讯作者：
Horwitz, Sarah McCue
DOI：
10.1016/j.jaac.2015.09.010
发表时间：
2015-12-01
影响因子：
13.3
作者：
Humphreys, Kathryn L.;McGoron, Lucy;Zeanah, Charles H.
通讯作者：
Zeanah, Charles H.
影响因子：
3.4
作者：
de Onis M;Branca F
通讯作者：
Branca F
影响因子：
4
作者：
James, Jenee;Ellis, Bruce J.;Garber, Judy
通讯作者：
Garber, Judy