Cytonuclear theory for haplodiploid species and X-linked genes. I. Hardy-Weinberg dynamics and continent-island, hybrid zone models.
Cytonuclear theory for haplodiploid species and X-linked genes. I. Hardy-Weinberg dynamics and continent-island, hybrid zone models.
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单倍二倍体物种和 X 连锁基因的细胞核理论。
DOI：
10.1093/genetics/147.1.321
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发表时间：
1997
期刊：
影响因子：
3.3
通讯作者：
Asmussen,MA
中科院分区：
文献类型：
--
作者：
Goodisman,MA;Asmussen,MA
我们开发的模型描述单倍二倍体物种中的细胞质和核标记或二倍体物种中的细胞质和X连锁标记的细胞核结构。定义了总结此类系统中非随机细胞核关联的性别特异性不平衡统计数据，并界定了它们的基本 Hardy-Weinberg 动力学和混合公式。我们专注于混合区的背景，并开发大陆-岛屿模型，来自两个遗传差异源群体的个体迁移到单个混合区并在其中交配。我们研究了性别差异迁移、纯型雌性的选型交配、普查时间（相对于交配和迁移）以及一般模型下随机交配和迁移的特殊情况的影响。我们表明，如果两个源群体持续迁移，纯型个体和非零细胞核不平衡可以在混合区域内维持，并且雌性通常比雄性对这些细胞核变量有更大的影响。由此产生的理论框架可用于估计杂交区域和涉及单倍二倍体或性别相关细胞核数据的其他混合区域中选型交配和性别特异性基因流的速率。
We develop models that describe the cytonuclear structure for either a cytoplasmic and nuclear marker in a haplodiploid species or a cytoplasmic andX-linked marker in a diploid species. Sex-specific disequilibrium statistics that summarize nonrandom cytonuclear associations in such systems are defined, and their basic Hardy-Weinberg dynamics and admixture formulae are delimited. We focus on the context of hybrid zones and develop continent-island models whereby individuals from two genetically differentiated source populations migrate into and mate within a single zone of admixture. We examine the effects of differential migration of the sexes, assortative mating by pure type females, and census time (relative to mating and migration), as well as special cases of random mating and migration subsumed under the general models. We show that pure type individuals and nonzero cytonuclear disequilibria can be maintained within a hybrid zone if there is continued migration from both source populations, and that females generally have a greater influence over these cytonuclear variables than males. The resulting theoretical framework can be used to estimate the rates of assortative mating and sex-specific gene flow in hybrid zones and other zones of admixture involving haplodiploid or sex-linked cytonuclear data.