Editors' Choice-Review-The Future of Carbon-Based Neurochemical Sensing: A Critical Perspective.
Editors' Choice-Review-The Future of Carbon-Based Neurochemical Sensing: A Critical Perspective.
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DOI：
10.1149/2754-2726/ad15a2
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发表时间：
2023-12-01
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碳基传感器仍然是神经化学物质电化学检测的关键材料，这源于其固有的生物相容性和广泛的潜在窗口。使用快速扫描循环伏安法的实时监测导致微创碳纤维微电极作为组织测量的首选材料的兴起，但碳纤维固有特性的挑战限制了其对未充分研究的神经化学物质的适用性。在这里，我们对碳基实时神经化学检测的状态进行了严格的审查，并提供了我们设想在未来解决这些限制的方法。这篇文章重点介绍了传统碳纤维基材料的三个主要障碍：由于材料的几何特性和吸附/解吸特性而导致的时间分辨率降低，对大多数神经化学物质的选择性/特异性差，以及无法调整非晶碳表面的特定界面相互作用。解决这些挑战的途径可能在于单分子界面相互作用的计算建模，可调碳基材料的扩展以及合成这些材料的新方法。我们希望这篇重要的文章能够公正地描述在这项工作之前的新型碳基材料，我们希望这篇评论为未来个性化神经化学结构的碳基材料开发提供有用的解决方案。回顾碳纤维微电极用于神经化学传感的局限性。可调碳基传感器设计的未来。学术上可获得的综合方法需求。界面吸附相互作用的分子动力学模拟的必要性。
Carbon-based sensors have remained critical materials for electrochemical detection of neurochemicals, rooted in their inherent biocompatibility and broad potential window. Real-time monitoring using fast-scan cyclic voltammetry has resulted in the rise of minimally invasive carbon fiber microelectrodes as the material of choice for making measurements in tissue, but challenges with carbon fiber’s innate properties have limited its applicability to understudied neurochemicals. Here, we provide a critical review of the state of carbon-based real-time neurochemical detection and offer insight into ways we envision addressing these limitations in the future. This piece focuses on three main hinderances of traditional carbon fiber based materials: diminished temporal resolution due to geometric properties and adsorption/desorption properties of the material, poor selectivity/specificity to most neurochemicals, and the inability to tune amorphous carbon surfaces for specific interfacial interactions. Routes to addressing these challenges could lie in methods like computational modeling of single-molecule interfacial interactions, expansion to tunable carbon-based materials, and novel approaches to synthesizing these materials. We hope this critical piece does justice to describing the novel carbon-based materials that have preceded this work, and we hope this review provides useful solutions to innovate carbon-based material development in the future for individualized neurochemical structures. Review limitations of carbon-fiber microelectrodes for neurochemical sensing. Future of tunable carbon-based sensor design. Academically-accessible synthesis approach needs. Need for molecular dynamic simulations of interfacial adsorption interactions.