Stripping voltammetric behaviour of toxic drug nitrofurantoin.
Stripping voltammetric behaviour of toxic drug nitrofurantoin.
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DOI：
10.1016/j.jhazmat.2009.03.138
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发表时间：
2009-09
影响因子：
13.6
通讯作者：
R. Jain;A. Dwivedi;R. Mishra
中科院分区：
文献类型：
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作者：
R. Jain;A. Dwivedi;R. Mishra
开发了一种简单、灵敏、重复性好的方波阴极吸附溶出伏安法，用于测定溶解体系中的呋喃妥因。本文的目的是通过使用不同的伏安技术研究呋喃妥因的氧化还原行为，并建立在表面活性剂存在下测定其的方法。在 pH 2-11 的磷酸盐缓冲液中，药物与西曲溴铵的伏安图显示出一个明确的还原峰，这可能归因于 –NO2 基团的还原。在整个研究的 pH 范围内，还原过程是不可逆的。基于可控电位电解、库仑分析和光谱分析，推测了还原机理。所提出的 SWCAdSV 伏安法可以测定线性浓度范围 2×10−5 至 1×10−7molL−1 内的呋喃妥因。检测下限 (LOD) 和定量下限 (LOQ) 分别为 0.06 和 0.27ng/mL。
A simple, sensitive and reproducible squarewave cathodic adsorptive stripping voltammetric method has been developed for the determination of nitrofurantoin in solubilized system. The objective of the present paper is to investigate the redox behaviour of nitrofurantoin by using different voltammetric techniques and to establish the methodology for its determination in the presence of surfactants. Voltammograms of the drug with cetrimide in phosphate buffers of pH 2–11 exhibited a single well-defined reduction peak which may be attributed to the reduction of –NO2group. The reduction process is irreversible over the entire pH range studied. The mechanism of reduction has been postulated on the basis of controlled potential electrolysis, coulometry and spectral analysis. The proposed SWCAdSV voltammetric method allows the determination of nitrofurantoin in linear concentration range 2×10−5to 1×10−7molL−1. The lower limit of detection (LOD) and lower limit of quantification (LOQ) are 0.06 and 0.27ng/mL, respectively.