Changing trends of antimicrobial susceptibility patterns of Neisseria gonorrhoeae in India and the emergence of ceftriaxone less susceptible N-gonorrhoeae strains
Changing trends of antimicrobial susceptibility patterns of Neisseria gonorrhoeae in India and the emergence of ceftriaxone less susceptible N-gonorrhoeae strains
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DOI：
10.1093/jac/dkm238
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发表时间：
2007-09-01
影响因子：
5.2
通讯作者：
Jain, R. K.
中科院分区：
文献类型：
--
作者：
Bala, Manju;Ray, Krishna;Jain, R. K.
目的：根据淋球菌抗菌药物敏感性计划，监测2002年至2006年印度新德里淋球菌分离株的抗菌药物敏感性趋势，并记录任何新的抗菌药物耐药性的出现。以WHO参考菌株为对照，采用纸片扩散法测定了男性和女性淋病临床病例中的淋病分离株对青霉素、四环素、环丙沙星、大观霉素和头孢曲松的敏感性。结果：青霉素和环丙沙星耐药性的显着增加趋势，分别到2003年和2004年，随后减少耐药菌株，同时增加敏感性较低的菌株，观察。四环素抗性N.淋病从2002年的6.7%大幅上升至2005年的22.9%。在这5年期间，只有1株分离株对壮观霉素耐药，9株分离株对头孢曲松敏感性较低。相当比例的菌株（23.3%）是多重耐药的。淋病分离株是一个令人关切的问题，尽管没有观察到治疗失败。需要在许多实验室建立一个积极、持续和全面的抗菌素耐药性监测和监视方案，并需要开始寻找新的有效药物，以应对耐药菌株的出现。
Objectives: To monitor the trend of antimicrobial susceptibility of Neisseria gonorrhoeae isolates from 2002 to 2006 in New Delhi, India under the Gonococcal Antimicrobial Susceptibility Programme and to document the emergence of any new antimicrobial resistance.Methods: Antimicrobial susceptibility of 382 N. gonorrhoeae isolates from clinical cases in males and females to penicillin, tetracycline, ciprofloxacin, spectinomycin and ceftriaxone was determined by disc diffusion technique, using WHO reference strains as controls and WHO interpretative criteria. MICs were determined using Etests.Results: A significant increasing trend of penicillin and ciprofloxacin resistance up to 2003 and 2004, respectively, and subsequent decrease in resistant strains with a concomitant increase in less susceptible strains, was observed. Tetracycline-resistant N. gonorrhoeae increased significantly from 6.7% in 2002 to 22.9% in 2005. Only one isolate was resistant to spectinomycin and nine isolates were less susceptible to ceftriaxone, during this 5 year period. A substantial proportion (23.3%) of strains were multiresistant.Conclusions: Emergence of ceftriaxone less susceptible N. gonorrhoeae isolates is a cause for concern, although treatment failure was not observed. An active, continuous and comprehensive programme for monitoring and surveillance of antimicrobial resistance needs to be established in many laboratories, and a search for new effective agents needs to be initiated to respond to the emergence of resistant isolates.