Improved Cognitive Promotion through Accelerated Magnetic Stimulation
Improved Cognitive Promotion through Accelerated Magnetic Stimulation
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DOI：
10.1523/eneuro.0392-20.2020
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发表时间：
2021-01-01
期刊：
影响因子：
3.4
通讯作者：
Wang, Kai
中科院分区：
文献类型：
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作者：
Wu, Xingqi;Wang, Lu;Wang, Kai
非侵入性脑刺激以增强认知是一个越来越受关注的研究领域。Theta burst stimulation（TBS）是一种新型的加速刺激形式，它更接近地模仿大脑的自然放电模式，并可能对认知性能产生更大的影响。我们在这里报告了传统高频重复经颅磁刺激（HF-rTMS）方案和TBS方案对健康对照认知增强效果的比较评估。将60名健康成年人（34名男性和26名女性）随机化并平衡，并分配到HF-rTMS（n = 20），TBS（n = 20）或假手术（n = 20）组。通过N-back任务和威斯康星州卡片分类测验（WCST），比较不同参数的前额叶刺激对工作记忆和执行功能的促进作用。HF-rTMS和间歇性TBS（iTBS）组在N-back任务中均显示出显著改善，效应量分别为0.79和1.50。此外，iTBS组在WCST方面表现出显著改善，效应量为0.84。iTBS组的效应量高于HF-rTMS组（t = 2.68，p = 0.011），效应量为0.85。然而，在其他任务中没有观察到改善（p > 0.05）。间歇性TBS比常规rTMS具有更强的认知促进作用。总之，我们的研究结果提供了直接的证据，iTBS可能是一个上级协议的认知促进。
Noninvasive brain stimulation to enhance cognition is an area of increasing research interest. Theta burst stimulation (TBS) is a novel accelerated form of stimulation, which more closely mimics the brain's natural firing patterns and may have greater effects on cognitive performance. We report here the comparative assessment of the effect of conventional high-frequency repetitive transcranial magnetic stimulation (HF-rTMS) protocols and TBS protocols on cognition enhancement in healthy controls. Sixty healthy adults (34 males and 26 females) were randomized and counterbalanced and assigned to HF-rTMS (n = 20), TBS (n = 20), or sham (n = 20) groups. The promotion effects of different parameters of prefrontal stimulation on working memory and executive function were compared, as assessed by performance in N-back tasks and the Wisconsin Card Sorting Test (WCST). Both HF-rTMS and intermittent TBS (iTBS) groups displayed a significant improvement in N-back tasks, with an effect size of 0.79 and 1.50, respectively. Furthermore, the iTBS group displayed a significant improvement in the WCST, with an effect size of 0.84. The iTBS group demonstrated higher effect sizes than the HF-rTMS group (t = 2.68, p = 0.011), with an effect size of 0.85. However, no improvement in other tasks was observed (p > 0.05). Intermittent TBS has a stronger cognitive promoting effect than conventional rTMS. In summary, our findings provide direct evidence that iTBS may be a superior protocol for cognitive promotion.