Enkephalin and substance P effects related to trigeminal pain.
Enkephalin and substance P effects related to trigeminal pain.
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脑啡肽和 P 物质对三叉神经疼痛的影响。
DOI：
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发表时间：
1978
影响因子：
2.1
通讯作者：
E. Puil
中科院分区：
文献类型：
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作者：
R. Andersen;J. P. Lund;E. Puil
脑啡肽 (20-150 nA) 的离子电渗疗法降低了去大脑猫三叉神经尾核中伤害性神经元的自发放电频率。在使用阿片类药物的第一分钟内，由有害刺激（牙髓）引起的反应逐渐被抑制，并且在电流关闭后通常保持抑制状态 5 分钟。脑啡肽的这些作用可以被静脉内或离子导入纳洛酮阻断。非伤害性神经元或对非伤害性输入做出反应的伤害性神经元较少被脑啡肽抑制。当对非伤害性细胞进行测试时，类似的 P 物质应用通常效果甚微。然而，伤害性神经元会被 P 物质强烈兴奋。这种作用不是恒定的，并且会被失活时期所打断。两种类型的肽作用在时间方面相似。结果表明，在介导伤害感受的三叉神经系统中，脑啡肽和 P 物质之间存在功能上的相互关系。
Iontophoretic applications of enkephalin (20-150 nA) reduced the spontaneous firing frequency of nociceptive neurons in the trigeminal nucleus caudalis of decerebrated cats. The response evoked by noxious stimulation (tooth pulp) was gradually inhibited during the 1st minute of application of the opioid and generally remained depressed for 5 min after the current was turned off. These effects of enkephalin were blocked by intravenously or iontophoretically administered naloxone. Nonnociceptive neurons or nociceptive neurons responding to nonnoxious inputs were less frequently inhibited by enkephalin. When tested on nonnociceptive cells, similar applications of substance P usually had little effect. Nociceptive neurons, however, were strongly excited by substance P. This action was not constant and was interrupted by periods of inactivation. Both types of peptide action were similar in temporal aspects. The results suggest a functional interrelationship between enkephalin and substance P in a trigeminal system mediating nociception.