New Functions of Polysialic Acid and Its Relationship to Schizophrenia
New Functions of Polysialic Acid and Its Relationship to Schizophrenia
复制标题
聚唾液酸的新功能及其与精神分裂症的关系
DOI：
10.4052/tigg.23.221
复制
发表时间：
2011
影响因子：
0.3
通讯作者：
K. Kitajima
中科院分区：
文献类型：
--
作者：
C. Sato;K. Kitajima
Polysialic acid (polySia), particularly α2,8-linked polyNeu5Ac (DP=8~400), is a unique polymer that spatiotemporally modifies neural cell adhesion molecule (NCAM), predominantly in embryonic brains. PolySia is considered to function as a negative regulator of adhesion between cells, and between cells and extracellular matrix due to its extremely polyanionic nature and steric hindrance. Through its antiadhesive property and spatio-temporal expression, polySia is involved in cell migration, neural outgrowth, axonal guidance, synaptic plasticity, and the development of normal neural circuits and neurogenesis. Due to improvements of polySiadetection methods, it has been shown that polySia expression persists in the hippocampus and olfactory bulb of adults, where neurogenesis is ongoing; however, the functions of polySia, particularly in adult brains, remain incompletely resolved. Recently, we demonstrated that polySia functions not only as an anti-adhesive molecule, but also as a reservoir for specific bioactive molecules, such as neurotrophic factors, neurotransmitters, and growth factors, which regulate neural function. In addition, studies have revealed that the enzymatic activity of STX, which is involved in the synthesis of polySia, derived from schizophrenic patient is low and that the product of the enzyme, polySia on NCAM is impaired with respect to both quantity and quality. Notably, impaired polySia-NCAM cannot effectively retain bioactive molecules, including BDNF, dopamine, and FGF2. Taken together, the impairment of polySia might influence the retention function of polySia and lead to the development of psychiatric disorders, such as schizophrenia, which are reported to express either lower or elevated amounts of polySia compared with normal brains. A. Introduction The sialic acids are a family of 2-keto-3-deoxy nononic acid substitutions and are 9-carbon carboxylated sugars with a single negative charge derived from a carboxyl group at the C-1 position. Sialic acids consist of three basic structures, N-acetylneuraminic acid (Neu5Ac), N-glycolylneuraminic ポリシアル酸の新機能と統合失調症
唾液酸链长多样性...
DOI：
--
发表时间：
2004
期刊：
Trends in Glycoscience and Glycotechnology 16
影响因子：
--
作者：
佐藤ちひろ;北島 健;佐藤ちひろ;C.Sato
通讯作者：
C.Sato
海胆配子中的聚唾液酸
DOI：
--
发表时间：
2007
期刊：
Trends Glycosci Glycotech. 19
影响因子：
--
作者：
Miyata;S. Sato C. and Kitajima;K.
通讯作者：
K.