Can We Be Optimistic about Asthma in Childhood? A Greek Cohort Study
Can We Be Optimistic about Asthma in Childhood? A Greek Cohort Study
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DOI：
10.1080/02770900802553128
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发表时间：
2009-01-01
影响因子：
1.9
通讯作者：
Bakoula, Chryssa
中科院分区：
文献类型：
--
作者：
Bacopoulou, Flora;Veltsista, Alexandra;Bakoula, Chryssa
客观的。研究以希腊人口为基础的出生队列中哮喘从儿童期到青春期的患病率和自然病程，并确定相关因素。方法。获得了 2133 名 7 岁和 18 岁儿童的经医生诊断和治疗的哮喘症状的纵向信息。结果。目前哮喘患病率在 7 岁和 18 岁时分别为 9.0% 和 5.0%。 18 岁时终生哮喘患病率为 26.3%。超过一半的早发性哮喘儿童（58.2%）在 7 岁时没有症状，只有 7.6% 在青春期持续出现症状。然而，48.2% 的迟发性哮喘患者的症状持续长达 18 年。 Logistic回归分析显示，男性、特应性家族史、青少年活跃吸烟和母亲吸烟与18岁时终生哮喘呈显着正相关。此外，怀孕期间吸烟与 18 岁时持续出现哮喘症状的风险增加相关。儿童时期的哮喘与青少年时期的主动吸烟呈正相关，而每天食用水果和蔬菜与 18 岁时当前的哮喘呈负相关。最后，母乳喂养的儿童在 7 岁时患终生哮喘的风险较低。结论。在整个希腊，7 岁和 18 岁年龄段哮喘症状的患病率较低。我们的研究结果表明，营养是希腊儿童哮喘的一个重要相关因素。
Objective. To examine the prevalence and natural course of asthma from childhood to adolescence in a population-based, Greek birth cohort and to identify associated factors. Methods. Longitudinal information on asthma symptoms, physician diagnosed and treated, was available for 2133 children at 7 and 18 years of age. Results. The prevalence of current asthma was 9.0% and 5.0% at 7 and 18 years, respectively. The prevalence of lifetime asthma was 26.3% at 18 years. More than half of the children (58.2%) with early onset asthma were asymptomatic at 7 years and only 7.6% continued to have symptoms during adolescence. However, in 48.2% of those with late onset asthma, symptoms persisted up to 18 years. Logistic regression analyses showed that male gender, family history of atopy, active adolescent smoking and maternal smoking were significantly positively associated with lifetime asthma at 18 years. In addition, smoking during pregnancy was associated with an increased risk for persistence of asthma symptoms at 18 years. Asthma during childhood and active adolescent smoking were positively associated, and daily consumption of fruit and vegetables was negatively associated with current asthma at 18 years of age. Finally, children who were breastfed had a lower risk for lifetime asthma at 7 years. Conclusion. The prevalence of asthma symptoms at 7 and 18 years of age was low throughout Greece. Our results suggest that, among others, nutrition is an important correlate of asthma in Greek children.