Further evidence that luteinizing hormone-releasing hormone also is follicle-stimulating hormone-releasing hormone.
Further evidence that luteinizing hormone-releasing hormone also is follicle-stimulating hormone-releasing hormone.
复制标题
进一步的证据表明黄体生成素释放激素也是卵泡刺激素释放激素。
作者：
P. M. Wise;Naomi Rance;George D. Barr;C. Barraclough
虽然LHRH在广泛的实验条件下引起LH和FSH的释放，但这种激素尚未显示出在不伴随LH释放的情况下诱导FSH的释放。因此，没有排除存在单独的FSHRH的可能性。这些实验旨在证明LHRH能够促进血浆FSH的显著增加，同时血浆LH的生理学变化不显著，因此LHRH也是FSHRH。7组周期性雌性大鼠在发情前期1200 h接受苯巴比妥以阻断自发排卵前LH和FSH峰。然后根据是否输注磷酸盐缓冲盐水（PBS）、LHRH或两者同时输注（iv），将这些不同的组进行细分。实验方案包括输注材料初始30分钟（预充期），停止输注30分钟（休息间隔），并再次输注材料额外210分钟（维持期）。当PBS在预充过程中注入时...
While LHRH evokes the release of both LH and FSH under a wide spectrum of experimental conditions, this hormone has not been shown to induce the discharge of FSH unaccompanied by LH release. As a consequence, the possibility that a separate FSHRH exists has not been discounted. These experiments were designed to demonstrate that LHRH is capable of promoting marked increases in plasma FSH concomitant with physiologically insignificant changes in plasma LH and, thus, that LHRH is also FSHRH. Seven groups of cyclic female rats received phenobarbital at 1200 h proestrus to block spontaneous preovulatory LH and FSH surges. These various groups then were subdivided according to whether phosphate-buffered saline (PBS), LHRH, or both was infused (iv). The experimental protocol consisted of infusing material for an initial 30 min (priming period), stopping the infusion for 30 min (rest interval), and again infusing material for an additional 210 min (maintenance period). When PBS was infused during the priming and...