Erbium:YAG laser lithotripsy using hybrid germanium/silica optical fibers.
Erbium:YAG laser lithotripsy using hybrid germanium/silica optical fibers.
复制标题
使用混合锗/石英光纤进行铒：YAG 激光碎石术。
DOI：
10.1089/end.2004.18.830
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发表时间：
2004
影响因子：
2.7
通讯作者：
Fried,NathanielM
中科院分区：
文献类型：
--
作者：
Yang,Yubing;Chaney,CharlesA;Fried,NathanielM
背景和目的：先前的研究表明，铒：YAG激光的激光碎石效率是钬：YAG激光的2 - 3倍。然而，缺乏合适的光纤传输系统仍然是Er：YAG激光碎石术临床应用的主要障碍。本文描述了混合氧化锗/二氧化硅光纤与Er：YAG激光器一起用于内窥镜的初步测试。材料和方法：波长为2.94 µm、脉冲能量为10至600 mJ、脉冲长度为220 µsec、脉冲重复频率为3至10 Hz的Er：YAG激光辐射聚焦到与人体尿酸或草酸钙一水合物结石接触的350或425 µ m芯混合锗/二氧化硅光纤中。结果：在观察到纤维损伤之前，通过与泌尿系结石接触的425 µm混合光纤以10 Hz输送的平均Er：YAG脉冲能量为157 ± 46 mJ（66 J/cm 2）（N = 8）。还通过与结石接触的混合纤维测量到233 mJ（98 J/cm 2）的最大脉冲能量。这些值明显大于15至23 mJ的结石消融阈值（6-10 J/cm 2），氧化锗的纤维损伤阈值为18 ± 1 mJ（13 J/cm 2），蓝宝石，73 mJ（51 J/cm 2），Er：YAG激光碎石术期间的光纤结论：对于Er：YAG激光在玻璃体碎石术中的应用。
Background and Purpose:Previous studies have demonstrated that the erbium:YAG laser is two to three times more efficient for laser lithotripsy than the holmium:YAG laser. However, the lack of a suitable optical fiber delivery system remains a major obstacle to clinical application of Er:YAG laser lithotripsy. This paper describes the initial testing of a hybrid germanium oxide/silica optical fiber for potential endoscopic use with the Er:YAG laser.Materials and Methods:Er:YAG laser radiation with a wavelength of 2.94 µm, a pulse energy of 10 to 600 mJ, a pulse length of 220 µsec, and pulse-repetition rates of 3 to 10 Hz was focused into either 350- or 425- µm-core hybrid germanium/silica fibers in contact with human uric acid or calcium oxalate monohydrate stones.Results:Average Er:YAG pulse energies of 157 ± 46 mJ (66 J/cm2) (N = 8) were delivered at 10 Hz through the 425-µm hybrid fibers in contact with urinary stones before fiber damage was observed. A maximum pulse energy of 233 mJ (98 J/cm2) was also measured through the hybrid fiber in contact with the stones. These values are significantly greater than the stone ablation thresholds of 15 to 23 mJ (6–10 J/cm2) and the fiber damage thresholds measured for germanium oxide, 18 ± 1 mJ (13 J/cm2), and sapphire, 73 mJ (51 J/cm2), optical fibers during Er:YAG laser lithotripsy (P< 0.05).Conclusions:A prototype hybrid germanium/silica optical fiber demonstrated better performance than both germanium oxide and sapphire fibers for transmission of Er:YAG laser radiation duringin vitrolithotripsy.