The Pigment-Dispersing Hormone Family: Chemistry, Structure-Activity Relations, and Distribution
The Pigment-Dispersing Hormone Family: Chemistry, Structure-Activity Relations, and Distribution
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色素分散激素家族：化学、结构-活性关系和分布
DOI：
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发表时间：
1989
期刊：
影响因子：
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通讯作者：
J. Riehm
中科院分区：
文献类型：
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作者：
K. Rao;J. Riehm
本文总结了最近的工作色素分散激素（PDH）家庭，一组相关的神经肽常见的节肢动物。已知psi玛丽结构是几种甲壳类物种（Pandalus borealis，Uca pugi！作者，癌症专家，南美白对虾，Procam barus c！arkii）和两种昆虫（Achetaparticus，Romaleamicroptera）的相关色素分散因子。在该肽家族中，氨基酸链长（18个残基）、末端（N-末端Asn、C-末端Ala-NH 2）和至少50%的序列是保守的。合成类似物已被用于分析PDH的结构-活性关系，导致：特定残基的作用的评估;信息序列的试探性鉴定;和稳定的和超强的类似物的制备，包括用于放射性碘标记的酪氨酸类似物。建立了一种检测@9-PDH的酶联免疫吸附试验（ELISA）。抗α-PDH和β-PDH的抗血清用于测定PDH的分布。这种分布和其他证据表明，除了在人类道德调节的猪系统的作用，PDH可能服务于额外的猪功能。PDH相关肽在昆虫中的功能尚不清楚。
This report summarizes recent work on the pigment-dispersing hormone (PDH) family, a set of re lated neuropeptides common to arthropods. The psi mary structures are known for the major form of PDH in several crustacean species (Pandalus borealis, Uca pugi!ator, Cancer magister, Penaeus aztecus, Procam barus c!arkii) and for related pigment-dispersing factors from two insects (Acheta domesticus, Romalea micro ptera). In this peptide family, the amino acid chain length (18 residues), termini (N-terminal Asn, C-termi nal Ala-NH2), and at least 50% ofthe sequence are con served. Synthetic analogs have been used to analyze the structure-activity relations ofPDH, leading to: an evalu ation of the role of specific residues; a tentative identifi cation of the message sequence; and the preparation of stable and superpotent analogs including tyrosinated an alogs for radioiodination. An enzyme-linked immuno sorbant assay (ELISA) has been developed for @9-PDH. Antisera raised against a-PDH and f@-PDH were used to determine the distribution of PDH. This distribution and other evidence indicate that, besides its role in hu moral regulation of the pigmentary system, PDH may serve extra-pigmentary functions. The functions of the PDH-related peptides in insects are unknown.