NORMATIVE DISTRIBUTION OF COMPLETE BLOOD-COUNT FROM EARLY-CHILDHOOD THROUGH ADOLESCENCE - THE BOGALUSA HEART-STUDY
NORMATIVE DISTRIBUTION OF COMPLETE BLOOD-COUNT FROM EARLY-CHILDHOOD THROUGH ADOLESCENCE - THE BOGALUSA HEART-STUDY
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DOI：
10.1006/pmed.1993.1075
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发表时间：
1993-11-01
影响因子：
5.1
通讯作者：
BERENSON, GS
中科院分区：
文献类型：
--
作者：
BAO, WH;DALFERES, ER;BERENSON, GS
背景注意到血液值的分布在一个births南部社区根据年龄，性别和种族的变化将有助于了解早期生活的规范发展变化，并提供背景信息。作为心血管危险因素筛查的一部分，从一个明确的黑人-白人社区的3,018名5-17岁自由生活的儿童中获得全血细胞计数。5-17岁儿童的血红蛋白水平、红细胞压积、平均红细胞体积、平均红细胞血红蛋白和红细胞计数随年龄增长而增加（P< 0.01）。血小板计数和白色细胞计数随年龄增长而下降（P< 0.0005）。12 ~ 17岁男性红细胞计数高于女性（P< 0.05）0.4 × 1012/L。血红蛋白升高1 g/dl，红细胞压积升高2%，平均红细胞血红蛋白浓度升高0.2 g/dl，白色血细胞计数降低0.5 × 109/L。1.4平均红细胞体积降低1/l，平均红细胞血红蛋白降低0.3 pg，血小板计数降低14 × 109/L。与黑人相比，白人的白色血细胞计数高出0.5 × 109/升（P< 0.05），红细胞计数高出0.05 × 1012/升，血红蛋白高出0.7 g/dl，红细胞压积高出1.7%，平均红细胞体积高出2.4 fl，平均红细胞血红蛋白高出1 pg，平均红细胞血红蛋白浓度高出0.5 g/dl。血细胞计数和血红蛋白与血压呈正相关，与成人血压相似。血液值因年龄、性别和种族而异。这些差异在成熟时发生变化，在定义正常和“异常”血液值时应予以考虑。
Background. Noting the distribution of blood values in a biracial southern community according to age, sex, and race variations will help in understanding the normative developmental changes in early life and provides background information.Methods. Complete blood counts were obtained from 3,018 free-living children ages 5-17 years from a well-defined black-white community as part of a cardiovascular risk factor screening.Results. For children ages 5-17 years, hemoglobin levels, hematocrit, mean corpuscular volume, mean corpuscular hemoglobin, and red blood count increased (P< 0.01) with age. Levels of platelet count and white blood count decreased (P< 0.0005) with age. Compared with females, males between ages 12 and 17 years have (P< 0.05) 0.4 × 1012/liter higher red blood count. 1 g/dl higher hemoglobin, 2% higher hematocrit, 0.2 g/dl higher mean corpuscular hemoglobin concentration, 0.5 × 109/liter lower white blood count. 1.4 fl lower mean corpuscular volume, 0.3 pg lower mean corpuscular hemoglobin, and 14 × 1O9/liter lower platelet count. Compared with blacks, whites have (P< 0.05) 0.5 109/liter higher white blood count, 0.05 1012/liter higher red blood count, 0.7 g/dl higher hemoglobin, 1.7% higher hematocrit, 2.4 fl higher mean corpuscular volume, 1 pg higher mean corpuscular hemoglobin, and 0.5 g/dl higher mean corpuscular hemoglobin concentration. A positive association was noted among blood count variables and hemoglobin with blood pressure similar to that in adults.Conclusion. Blood values differ by age, sex, and race. These differences change at maturation and should be considered when defining normal and "abnormal" blood values.