Hip dGEMRIC in asymptomatic volunteers and patients with early osteoarthritis: The influence of timing after contrast injection
Hip dGEMRIC in asymptomatic volunteers and patients with early osteoarthritis: The influence of timing after contrast injection
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DOI：
10.1002/mrm.21190
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发表时间：
2007-04-01
影响因子：
3.3
通讯作者：
Burstein, Deborah
中科院分区：
文献类型：
--
作者：
Tiderius, Carl J.;Jessel, Rebecca;Burstein, Deborah
在静脉注射Gd-DTPA（2-）后30、65、100和135分钟，对8名无症状志愿者和10名早期髋关节骨关节炎（OA）患者进行髋关节延迟钆增强软骨MRI （dGEMRIC）检查。在无症状志愿者中，dGEMRIC指数（T-1(Gd)）在30至100分钟之间下降。在患者中，Gd- dtpa（2-）的冲洗速度更快，30分钟时T-1（Gd）较低，随着时间的推移没有明显变化。因此，较早的时间点在T，（Gd）上显示无症状和OA髋关节之间的间隔较大，时间物流更方便。然而，30 min时的T-1（Gd）在OA组有较大的标准差（SD），可能是由于冲洗斜率的变化。这种对成像窗口的敏感性可能不太适合考虑可重复性的纵向研究。在所有时间点，患者的T，（Gd）比无症状志愿者低20-30% (P < 0.003)，这表明dGEMRIC对早期髋关节OA的敏感性。
Eight asymptomatic volunteers and 10 patients with early hip osteoarthritis (OA) were investigated with hip delayed gadolinium-enhanced MRI of cartilage (dGEMRIC) at 30, 65, 100, and 135 min after IV injection with Gd-DTPA(2-). In asymptomatic volunteers there was a decrease in the dGEMRIC index (T-1(Gd)) between 30 and 100 min. In patients the wash-in of Gd-DTPA(2-) was faster, with a low T-1(Gd) at 30 min that did not change significantly over time. Therefore, earlier time points showed a larger separation in T,(Gd) between asymptomatic and OA hips, with more convenient timing logistics. However, T-1(Gd) at 30 min had a larger standard deviation (SD) in the OA group, possibly due to variability of the steep slope of wash-in. This sensitivity to the imaging window may be less desirable for longitudinal studies in which reproducibility is a concern. At all time points, T,(Gd) was 20-30% lower in patients than in asymptomatic volunteers (P < 0.003), which demonstrates the sensitivity of dGEMRIC to early hip OA.