Causal neural network of metamemory for retrospection in primates
Causal neural network of metamemory for retrospection in primates
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DOI：
10.1126/science.aal0162
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发表时间：
2017-01-13
期刊：
影响因子：
56.9
通讯作者：
Miyashita, Yasushi
中科院分区：
文献类型：
--
作者：
Miyamoto, Kentaro;Osada, Takahiro;Miyashita, Yasushi
我们知道我们有多自信：元认知对记忆状态的自我监控，即所谓的“元记忆”，能够根据过去的经验进行战略性和有效的信息收集。然而，元记忆是如何在大脑中实现的还不清楚。本研究探讨了猕猴元认知置信判断过程中元记忆的因果神经机制。通过功能性磁共振成像的全脑搜索，我们发现元记忆在前额叶9区（或9/46 d）的时间上遥远的事件，以及沿着在6区的最近的事件的神经相关。可逆失活的每个这些确定的基因座诱导双重分离的选择性损伤元认知判断性能的远程或最近的记忆，而不损害识别性能本身。研究结果表明，平行的元记忆流监督识别网络的远程和最近的记忆，而不有助于识别本身。
We know how confidently we know: Metacognitive self-monitoring of memory states, so-called "metamemory," enables strategic and efficient information collection based on past experiences. However, it is unknown how metamemory is implemented in the brain. We explored causal neural mechanism of metamemory in macaque monkeys performing metacognitive confidence judgments on memory. By whole-brain searches via functional magnetic resonance imaging, we discovered a neural correlate of metamemory for temporally remote events in prefrontal area 9 (or 9/46d), along with that for recent events within area 6. Reversible inactivation of each of these identified loci induced doubly dissociated selective impairments in metacognitive judgment performance on remote or recent memory, without impairing recognition performance itself. The findings reveal that parallel metamemory streams supervise recognition networks for remote and recent memory, without contributing to recognition itself.