Stereotactic body radiation therapy. Rationale, techniques, applications, and optimization.
Stereotactic body radiation therapy. Rationale, techniques, applications, and optimization.
复制标题
立体定向放射治疗。
作者：
D. Song;B. Kavanagh;S. Benedict;T. Schefter
立体定向放射治疗（SBRT）是一种快速发展的癌症治疗方法，其中以前为脑肿瘤放射外科开发的概念和技术适用于根除身体其他部位的肿瘤。放射外科的空间准确性、适形性和陡峭的辐射剂量梯度是其成功治疗颅内肿瘤的关键，在SBRT中应用于治疗各种颅外肿瘤。早期结果表明，各种低分次给药方案和定位/固定技术具有优异的反应率和低毒性。本文概述了SBRT用于特定适应症的原理和结果，描述了一些治疗方法，并讨论了未来研究的潜在领域。
Stereotactic body radiation therapy (SBRT) is a rapidly evolving cancer treatment method in which concepts and techniques previously developed for brain tumor radiosurgery are adapted to eradicate tumors elsewhere in the body. The spatial accuracy, conformality, and steep radiation dose gradients of radiosurgery, which have been critical to its success in the treatment of intracranial tumors, are applied in SBRT to treat a variety of extracranial tumors. Early results demonstrate excellent response rates and low toxicity with a variety of hypofractionated dose regimens and localization/immobilization techniques. This article provides an overview of the rationale and results of SBRT for specific indications, descriptions of some methods of treatment delivery, and discussion of potential areas of future investigation.