AGE-ACQUIRED RESISTANCE AND PREDISPOSITION TO REINFECTION WITH SCHISTOSOMA-HAEMATOBIUM AFTER TREATMENT WITH PRAZIQUANTEL IN MALI
AGE-ACQUIRED RESISTANCE AND PREDISPOSITION TO REINFECTION WITH SCHISTOSOMA-HAEMATOBIUM AFTER TREATMENT WITH PRAZIQUANTEL IN MALI
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DOI：
10.4269/ajtmh.1995.52.549
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发表时间：
1995-06-01
影响因子：
3.3
通讯作者：
DABO, A
中科院分区：
文献类型：
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作者：
ETARD, JF;AUDIBERT, M;DABO, A
年龄，以前的感染强度和暴露治疗后再感染血吸虫的影响进行了研究，在一个队列的468名受试者6岁及以上的生活在一个灌溉计划区在商场。S.在1989年至1991年期间，每年都测量血吸虫感染，但再感染研究期仅限于随访的最后一年。在主要的水接触点进行观察，记录了排出叉尾尾蚴的截形泡螺数量。计算每例受试者的累积暴露指数，其中考虑了接触时间、持续时间和类型以及软体动物学数据。单因素分析显示，再感染风险随年龄的增长而降低，随暴露和预处理强度的增加而增加。这些结果通过拟合logistic模型得到证实，该模型显示，15岁及以上儿童的风险比6-14岁儿童低7倍，而感染暴露和治疗前强度的线性趋势显着。这项研究支持年龄获得性再感染抵抗力的概念，并支持感染易感性，这提出了控制S.血吸虫感染
The effect of age, previous intensity of infection, and exposure on reinfection with Schistosoma haematobium after treatment was studied in a cohort of 468 subjects six years of age and over living in an irrigation scheme area in Mall. Prevalence and intensity of S. haematobium infection were measured each year between 1989 and 1991, but the reinfection study period was restricted to the last year of the follow-up. Observations were made at the principal water contact sites where the number of Bulinus truncatus shedding furcocercous cercariae was recorded. A cumulative index of exposure taking into account time, duration and type of contact, and malacologic data was calculated for each subject. Univariate analysis showed that the reinfection risk decreased with age and increased with exposure and pretreatment intensity. These results were confirmed by fitting a logistic model that showed that this risk was seven times lower among those 15 years of age and older than among the 6-14-year-old children, while linear trends with exposure to infection and pretreatment intensity were significant. This study supports the concept of an age-acquired resistance to reinfection and is in favor of a predisposition to infection that raises the question of a genetic factor controlling susceptibility/resistance to S. haematobium infection.