Quantitative evaluation of bone single-photon emission computed tomography using Z score analysis in patients with mandibular osteomyelitis.
Quantitative evaluation of bone single-photon emission computed tomography using Z score analysis in patients with mandibular osteomyelitis.
复制标题
使用 Z 评分分析对下颌骨髓炎患者的骨单光子发射计算机断层扫描进行定量评估。
DOI：
10.1007/s11282-019-00407-z
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发表时间：
2020
期刊：
影响因子：
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通讯作者：
Kurabayashi T.
中科院分区：
文献类型：
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作者：
Asai S;Nakamura S;Toriihara A;Tateishi U;Kurabayashi T.
目的骨闪烁扫描是一种功能成像，可以早期检测骨变化，为检测骨髓炎提供高灵敏度。本研究旨在建立一种下颌骨骨髓炎骨SPECT图像的定量评价方法，并通过与常规主观评价等结果的比较，证实该方法的可靠性。方法本研究纳入139例接受骨SPECT检查的疑似下颌骨骨髓炎患者。通过与颈椎的比较来主观评估下颌病变中的 Tc-99 m 摄取，并将其分为 5 组。为了定量评估 Tc-99 m 摄取，我们开发了解剖标准化，然后将 Z 分数分析应用于脑神经退行性疾病的诊断。为了确认可靠性，评估了主观评价和 Z 分数之间的相关性。此外，还评估了 Z 评分与提示骨髓炎的 CT 结果之间的关系。结果通过解剖标准化，体素值的相关系数显着改善。骨髓炎的Z评分与主观评价显着相关。这也与一些CT表现（骨吸收、骨膜反应、周围软组织炎症）有关。结论我们通过解剖标准化和Z分数分析，开发了下颌骨骨SPECT图像的定量评估方法，被认为有助于定量评估下颌骨骨髓炎。
ObjectivesBone scintigraphy is a functional imaging that allows early detection of bone changes, providing high sensitivity to detect osteomyelitis. The aims of this study were to develop a quantitative evaluation method for bone SPECT images of mandibular osteomyelitis, and to confirm the reliability of this method by comparing the results with the conventional subjective evaluation and other findings.MethodsThe study included 139 patients with suspected mandibular osteomyelitis who were examined by bone SPECT. Tc-99 m uptake in mandibular lesions was subjectively evaluated by comparing with that of cervical vertebrae and categorized into 5 groups. For quantitative evaluation of Tc-99 m uptake, we developed an anatomical standardization followed by Z-score analysis applied to the diagnosis of brain neurodegenerative disease. To confirm reliability, the correlation between subjective evaluation and Z-score was evaluated. Further, the relationship between the Z-score and CT findings suggestive of osteomyelitis was also evaluated.ResultsThe correlation coefficient of voxel values was significantly improved by anatomical standardization. The Z-score of osteomyelitis was significantly correlated with subjective evaluation. It was also related to some of the CT findings (bone absorption, periosteal reaction, surrounding soft tissue inflammation).ConclusionsWe developed the quantitative evaluation method of the mandible on bone SPECT images using anatomical standardization followed by Z-score analysis, and it was considered useful for evaluating mandibular osteomyelitis quantitatively.