Acupuncture for cancer-related fatigue in lung cancer patients: a randomized, double blind, placebo-controlled pilot trial
Acupuncture for cancer-related fatigue in lung cancer patients: a randomized, double blind, placebo-controlled pilot trial
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针灸治疗肺癌患者癌症相关性疲劳：一项随机、双盲、安慰剂对照试点试验
DOI：
10.1007/s00520-017-3812-7
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发表时间：
2017-12-01
影响因子：
3.1
通讯作者：
Xie, Jing
中科院分区：
文献类型：
--
作者：
Cheng, Chien-shan;Chen, Lian-yu;Xie, Jing
背景癌症相关性疲劳（CRF）是一种令人痛苦的症状，是肺癌患者最常见的令人不快的副作用，对临床护理人员来说处理起来具有挑战性。方法我们进行了一项随机、双盲、安慰剂对照的试点试验，以评估针灸对肺癌患者 CRF 的临床效果。 28 名患有 CRF 的患者被随机分配到主动针灸组或安慰剂针灸组，接受每周两次的穴位刺激（LI-4、Ren-6、St-36、KI-3 和 Sp-6），持续 4 周，然后进行 2 周的随访。主要结果是基于中文版简要疲劳量表（BFI-C）的 CFR 强度变化。作为次要终点，采用癌症治疗功能评估-肺癌子量表（FACT-LCS）来评估针灸对患者生活质量（QOL）的影响。在整个试验过程中对不良事件和治疗安全性进行了监测。结果我们的试点研究证明了在具有适当纳入标准和针灸治疗依从性良好的患者中的可行性。与接受安慰剂的参与者相比，接受主动针灸的 14 名参与者在 2 周时观察到 BFI-C 评分显着降低（P < 0.01）。在第 6 周，根据 BFI-C（P<0.001）和 FACT-LCS（P=0.002），症状进一步改善。两组不良事件发生率差异均无统计学意义（P>0.05）。结论疲劳是肺癌患者常见的症状。针灸可能是癌症姑息治疗中辅助治疗的一种安全可行的可选方法，并且需要适当的动力试验来评估针灸的效果。
BackgroundCancer-related fatigue (CRF) is a distressing symptom that is the most common unpleasant side effect experienced by lung cancer patients and is challenging for clinical care workers to manage.MethodsWe performed a randomized, double-blind, placebo-controlled pilot trial to evaluate the clinical effect of acupuncture on CRF in lung cancer patients. Twenty-eight patients presenting with CRF were randomly assigned to active acupuncture or placebo acupuncture groups to receive acupoint stimulation (LI-4, Ren-6, St-36, KI-3, and Sp-6) twice per week for 4 weeks, followed by 2 weeks of follow-up. The primary outcome was the change in intensity of CFR based on the Chinese version of the Brief Fatigue Inventory (BFI-C). As the secondary endpoint, the Functional Assessment of Cancer Therapy-Lung Cancer Subscale (FACT-LCS) was adopted to assess the influence of acupuncture on patients’ quality of life (QOL). Adverse events and safety of treatments were monitored throughout the trial.ResultsOur pilot study demonstrated feasibility among patients with appropriate inclusion criteria and good compliance with acupuncture treatment. A significant reduction in the BFI-C score was observed at 2 weeks in the 14 participants who received active acupuncture compared with those receiving the placebo (P< 0.01). At week 6, symptoms further improved according to the BFI-C (P< 0.001) and the FACT-LCS (P= 0.002). There were no significant differences in the incidence of adverse events in either group (P> 0.05).ConclusionFatigue is a common symptom experienced by lung cancer patients. Acupuncture may be a safe and feasible optional method for adjunctive treatment in cancer palliative care, and appropriately powered trials are warranted to evaluate the effects of acupuncture.