Cell Assemblies of the Basal Forebrain
Cell Assemblies of the Basal Forebrain
复制标题
DOI：
10.1523/jneurosci.4432-14.2015
复制
发表时间：
2015-02
期刊：
影响因子：
--
通讯作者：
David Tingley;A. Alexander;L. Quinn;A. Chiba;D. Nitz
中科院分区：
文献类型：
--
作者：
David Tingley;A. Alexander;L. Quinn;A. Chiba;D. Nitz
基底前脑包括几个不同的神经元亚群，它们具有到离散的皮质亚区集合的模块化投影模式。每个皮质区域通过前额叶皮质形成经常性的投射，到达它们接受传入的特定的基底前脑亚群。这种结构使基础前脑能够根据当前的处理需求选择性地调节皮质反应。从理论上讲，这种分布式网络的最佳功能将通过共同作用的基底前脑神经元之间的时间协调或“细胞集合”的出现而得到增强。本工作展示了在选择性注意任务中大鼠基底前脑神经元群体的组装形成。神经元对在贝塔频率时间窗口(55ms)内显示出有组织的共激活模式，而不考虑它们在不同的爆发性和非爆发性基底前脑亚群中的成员资格。因此，这些结果揭示了一个特定的时间框架，用于整合基础前脑网络中的信息和调节皮质反应性。
The basal forebrain comprises several heterogeneous neuronal subgroupings having modular projection patterns to discrete sets of cortical subregions. Each cortical region forms recurrent projections, via prefrontal cortex, that reach the specific basal forebrain subgroups from which they receive afferents. This architecture enables the basal forebrain to selectively modulate cortical responsiveness according to current processing demands. Theoretically, optimal functioning of this distributed network would be enhanced by temporal coordination among coactive basal forebrain neurons, or the emergence of “cell assemblies.” The present work demonstrates assembly formation in rat basal forebrain neuronal populations during a selective attention task. Neuron pairs exhibited coactivation patterns organized within beta-frequency time windows (55 ms), regardless of their membership within distinct bursting versus nonbursting basal forebrain subpopulations. Thus, the results reveal a specific temporal framework for integration of information within basal forebrain networks and for the modulation of cortical responsiveness.